1. Dopamine, like other catecholamines, is normally metabolized by the enzymes monoamino oxidase and catechol-ortho-methyl transferase but it can also undergo oxidation to potentially toxic products, that, in turn, can generate free radicals. 2. In the present paper the effect of neuroleptic drugs (chlorpromazine, trifluoperazine and clozapine) and serotonin on the in vitro oxidation of dopamine and on lipid peroxidation was examined. Serotonin, clozapine, chlorpromazine and trifluoperazine inhibit autoxidation of dopamine both at pH 7.4 and pH 8.5. Trifluoperazine appears more efficient than chlorpromazine while serotonin shows an inhibitory effect intermediate between those of trifluoperazine and chlorpromazine; clozapine has only a moderate effect. 3. The catalytic effect of trace metal seems irrelevant since chelating agents do not show any significant inhibition. 4. All the substances used show a strong antiperoxidative activity. 5. It is concluded that the molecular and biochemical properties of serotonin and neuroleptic drugs on brain dopamine autoxidation and lipid peroxidation could be related to their physiological and clinical effects on mental illness in general and schizophrenia in particular.

Inhibitory action of neuroleptic drugs and serotonin on dopamine autoxidation and lipid peroxidation

RIGOBELLO, MARIA PIA;BINDOLI, ALBERTO
1995

Abstract

1. Dopamine, like other catecholamines, is normally metabolized by the enzymes monoamino oxidase and catechol-ortho-methyl transferase but it can also undergo oxidation to potentially toxic products, that, in turn, can generate free radicals. 2. In the present paper the effect of neuroleptic drugs (chlorpromazine, trifluoperazine and clozapine) and serotonin on the in vitro oxidation of dopamine and on lipid peroxidation was examined. Serotonin, clozapine, chlorpromazine and trifluoperazine inhibit autoxidation of dopamine both at pH 7.4 and pH 8.5. Trifluoperazine appears more efficient than chlorpromazine while serotonin shows an inhibitory effect intermediate between those of trifluoperazine and chlorpromazine; clozapine has only a moderate effect. 3. The catalytic effect of trace metal seems irrelevant since chelating agents do not show any significant inhibition. 4. All the substances used show a strong antiperoxidative activity. 5. It is concluded that the molecular and biochemical properties of serotonin and neuroleptic drugs on brain dopamine autoxidation and lipid peroxidation could be related to their physiological and clinical effects on mental illness in general and schizophrenia in particular.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2517780
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