GC-MS determination of eleven amphetamine analogs and ephedrines in plasma, urine and hair samples after derivatization with 2,2,2 trichloroethyl chloroformate

A new analytical approach, based on liquid/liquid extraction, derivatization with 2,2,2 trichloroethyl chloroformate and gas chromatography-mass spectrometry, has been developed for the quali-quantitative analysis of amphetamine analogs and ephedrines in plasma, urine and hair samples. Analytes under study were amphetamine, methamphetamine, 2,5DMA (2,5-dimethoxyamphetamine), MDA (3,4-methyIenedioxyamphetamine), MDMA (3,4-methylenedioxymethamphetamine), DOM (2,5dimethoxy-4-methylamphetamine), MDEA (3,4-methylenedíoxyethylamphetamine), MBDB (Nmethyl- l-(3,4-methylenedioxyphenyl)-2-butanamine), BDB (3,4-(methylenedioxyphenyl)-2-butanamine), TMA (3,4,5-trimethoxyamphetamine), DOB (4-bromo-2,5-dimethoxyamphetamine), ephedrine, pseudoephedrine, and phenylpropanolamine