The para-bromobenzoyl group linked to the N-terminus of a helical peptide chain turned out to be useful as a CD probe in the determination of the relationship between C-alpha-configuration of coded and non-coded alpha-amino acids and peptide helix screw sense in solution. The results of the present conformational investigation agree well with published crystal-state structural data on the same peptides obtained using X-ray diffraction where the para-bromobenzoyl group helped us to solve the phase problem by virtue of its heavy atom (bromine).
The P-bromobenzamido Chromophore As A Circular Dichroic Probe For the Assignment of the Screw Sense of Helical Peptides
TONIOLO, CLAUDIO;FORMAGGIO, FERNANDO;
1994
Abstract
The para-bromobenzoyl group linked to the N-terminus of a helical peptide chain turned out to be useful as a CD probe in the determination of the relationship between C-alpha-configuration of coded and non-coded alpha-amino acids and peptide helix screw sense in solution. The results of the present conformational investigation agree well with published crystal-state structural data on the same peptides obtained using X-ray diffraction where the para-bromobenzoyl group helped us to solve the phase problem by virtue of its heavy atom (bromine).File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
