The para-bromobenzoyl group linked to the N-terminus of a helical peptide chain turned out to be useful as a CD probe in the determination of the relationship between C-alpha-configuration of coded and non-coded alpha-amino acids and peptide helix screw sense in solution. The results of the present conformational investigation agree well with published crystal-state structural data on the same peptides obtained using X-ray diffraction where the para-bromobenzoyl group helped us to solve the phase problem by virtue of its heavy atom (bromine).
The P-bromobenzamido Chromophore As A Circular Dichroic Probe For the Assignment of the Screw Sense of Helical Peptides
TONIOLO, CLAUDIO;FORMAGGIO, FERNANDO;
1994
Abstract
The para-bromobenzoyl group linked to the N-terminus of a helical peptide chain turned out to be useful as a CD probe in the determination of the relationship between C-alpha-configuration of coded and non-coded alpha-amino acids and peptide helix screw sense in solution. The results of the present conformational investigation agree well with published crystal-state structural data on the same peptides obtained using X-ray diffraction where the para-bromobenzoyl group helped us to solve the phase problem by virtue of its heavy atom (bromine).
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