The remarkable beta-sheet forming properties of the sparingly soluble, fully blocked dipeptide Ac-L-Ala-L-Thr(Palm)-NH2 were investigated in a variety of solvent mixtures by IR absorption. In particular, it was found that mixtures of halohydrocarbons and haloalcohols are extremely efficient for disrupting self-association and enhancing solubility of this peptide model compound.

An Infrared-absorption Study of Powerful Solvent Systems Useful For the Solution Synthesis of Sparingly Soluble Peptides

FORMAGGIO, FERNANDO;TONIOLO, CLAUDIO;
1995

Abstract

The remarkable beta-sheet forming properties of the sparingly soluble, fully blocked dipeptide Ac-L-Ala-L-Thr(Palm)-NH2 were investigated in a variety of solvent mixtures by IR absorption. In particular, it was found that mixtures of halohydrocarbons and haloalcohols are extremely efficient for disrupting self-association and enhancing solubility of this peptide model compound.
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2523502
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