Many recent developments in sequential analysis have been motivated by ethical requirements in the design of clinical trials together with the need of overcoming some difficulties of Wald's theory. The purpose of this paper is to give a review of recently proposed methods for planning sequential clinical trials. Non-Bayesian and non-strictly-decision oriented methods for testing hypotheses concerning a normal mean with immediate response are considered. Methods are classified on the basis of the kind of comparison for which they were originally intended. This distinction has, in fact, an immediate reflection on different behaviours of the Average Sample Number functions. A general class of parametric boundaries is described, which yields many of the existing methods as particular cases. © 1990.
Planning sequential clinical trials: a review
SALVAN, ALESSANDRA
1990
Abstract
Many recent developments in sequential analysis have been motivated by ethical requirements in the design of clinical trials together with the need of overcoming some difficulties of Wald's theory. The purpose of this paper is to give a review of recently proposed methods for planning sequential clinical trials. Non-Bayesian and non-strictly-decision oriented methods for testing hypotheses concerning a normal mean with immediate response are considered. Methods are classified on the basis of the kind of comparison for which they were originally intended. This distinction has, in fact, an immediate reflection on different behaviours of the Average Sample Number functions. A general class of parametric boundaries is described, which yields many of the existing methods as particular cases. © 1990.
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