The synthesis is reported of a series of glutamyl peptide analogs of the model substrate H-Ser-Glu-Glu-Glu-Glu-Glu-OH of casein kinase-2 (CK-2). A convenient HPLC method for the separation of slightly different acidic peptides is also reported. The site specificity of yeast casein kinase-2 (Y-CK2) is examined with the aid of synthesized peptide substrates.
Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2.
MARIN, ORIANO;CALDERAN, ANDREA;RUZZA, PAOLO;BORIN, GIANFRANCO;MEGGIO, FLAVIO;MARCHIORI, FERNANDO
1990
Abstract
The synthesis is reported of a series of glutamyl peptide analogs of the model substrate H-Ser-Glu-Glu-Glu-Glu-Glu-OH of casein kinase-2 (CK-2). A convenient HPLC method for the separation of slightly different acidic peptides is also reported. The site specificity of yeast casein kinase-2 (Y-CK2) is examined with the aid of synthesized peptide substrates.File in questo prodotto:
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