The synthesis is reported of a series of glutamyl peptide analogs of the model substrate H-Ser-Glu-Glu-Glu-Glu-Glu-OH of casein kinase-2 (CK-2). A convenient HPLC method for the separation of slightly different acidic peptides is also reported. The site specificity of yeast casein kinase-2 (Y-CK2) is examined with the aid of synthesized peptide substrates.

Synthetic peptides including acidic clusters as substrates of yeast casein kinase-2.

MARIN, ORIANO;CALDERAN, ANDREA;RUZZA, PAOLO;BORIN, GIANFRANCO;MEGGIO, FLAVIO;MARCHIORI, FERNANDO
1990

Abstract

The synthesis is reported of a series of glutamyl peptide analogs of the model substrate H-Ser-Glu-Glu-Glu-Glu-Glu-OH of casein kinase-2 (CK-2). A convenient HPLC method for the separation of slightly different acidic peptides is also reported. The site specificity of yeast casein kinase-2 (Y-CK2) is examined with the aid of synthesized peptide substrates.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2529456
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