Mitochondria have long been known to accumulate Ca2+ down the electrical gradient established by the respiratory chain. Recent work has shown that, despite the low affinity of their Ca2+ transporters, Ca2+ uptake into mitochondria always follows the stimulation of cells with agonists causing an increase of cytoplasmic Ca2+ concentration. This process can modulate cellular events as diverse as aerobic metabolism, cytoplasmic diffusion of Ca2+ signals and induction of apoptotic cell death.
Calcium Transport in Mitochondria
RIZZUTO, ROSARIO;BRINI, MARISA
2013
Abstract
Mitochondria have long been known to accumulate Ca2+ down the electrical gradient established by the respiratory chain. Recent work has shown that, despite the low affinity of their Ca2+ transporters, Ca2+ uptake into mitochondria always follows the stimulation of cells with agonists causing an increase of cytoplasmic Ca2+ concentration. This process can modulate cellular events as diverse as aerobic metabolism, cytoplasmic diffusion of Ca2+ signals and induction of apoptotic cell death.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
