Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.

Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane

NADAI, MATTEO;SATTIN, GIOVANNA;PALUMBO, MANLIO;RICHTER, SARA
2013

Abstract

Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2552332
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