Two cathelicidins have been identified in salmonids and other fish. We characterized the antimicrobial activity spectrum , mode of action and tissue expression of salmon cathelicidins. To evaluate gene expression and tissue distribution of CATH-1 and CATH-2, an in vivo experiment was performed infecting O. mikiss samples with the salmon pathogen Yersinia ruckeri and tissues have been collected at different times and analyzed by real time RT-PCR.Results contribute to a comparative understanding of the functions of cathelicidins in vertebrates.
Characterization of the salmonid cathelicidins and of their biological activities
VENIER, PAOLA;ROSANI, UMBERTO;IRATO, PAOLA;
2013
Abstract
Two cathelicidins have been identified in salmonids and other fish. We characterized the antimicrobial activity spectrum , mode of action and tissue expression of salmon cathelicidins. To evaluate gene expression and tissue distribution of CATH-1 and CATH-2, an in vivo experiment was performed infecting O. mikiss samples with the salmon pathogen Yersinia ruckeri and tissues have been collected at different times and analyzed by real time RT-PCR.Results contribute to a comparative understanding of the functions of cathelicidins in vertebrates.File in questo prodotto:
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