Advanced precancerous lesions in the liver.

Di Tommaso, L; Sangiovanni, A; Borzio, M; Park, Yn; Farinati, Fabio; Roncalli, M.

doi:10.1016/j.bpg.2013.03.015.

We will focus on precursors of the most common liver cancer, i.e. hepatocellular carcinoma (HCC), which takes place in 90% of cases in a hepatitis/cirrhotic setting. High grade dysplastic nodules (HG-DN) are small sizable nodules and the most advanced precancerous lesions of the liver, with a risk of malignant transformation of about 30-40% at 24 months. We will survey the diagnostic distinction between them and early HCC from a clinical, radiological and pathological point of view. The use of a diagnostic algorithm supported by international guidelines is the best practice to manage HG-DN and early HCC. There is no typical imaging for HG-DN, needing all of them to be biopsied for characterization. The natural history of HG-DN is not predictable in individual cases and additional markers should be validated to increase the diagnostic accuracy and predict the behaviour. The treatment of HG-DN is under investigation.

Titolo:	Advanced precancerous lesions in the liver.
Autori:	Di Tommaso L Sangiovanni A Borzio M Park YN FARINATI, FABIO Roncalli M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2013
Rivista:	BAILLIERE'S BEST PRACTICE & RESEARCH. CLINICAL GASTROENTEROLOGY
Abstract:	We will focus on precursors of the most common liver cancer, i.e. hepatocellular carcinoma (HCC), which takes place in 90% of cases in a hepatitis/cirrhotic setting. High grade dysplastic nodules (HG-DN) are small sizable nodules and the most advanced precancerous lesions of the liver, with a risk of malignant transformation of about 30-40% at 24 months. We will survey the diagnostic distinction between them and early HCC from a clinical, radiological and pathological point of view. The use of a diagnostic algorithm supported by international guidelines is the best practice to manage HG-DN and early HCC. There is no typical imaging for HG-DN, needing all of them to be biopsied for characterization. The natural history of HG-DN is not predictable in individual cases and additional markers should be validated to increase the diagnostic accuracy and predict the behaviour. The treatment of HG-DN is under investigation.
Handle:	http://hdl.handle.net/11577/2674455
Appare nelle tipologie:	01.01 - Articolo in rivista

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