Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.

Gene expression profiling in breast cancer: A clinical perspective.

CONTE, PIERFRANCO;
2013

Abstract

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.
2013
STAMPA
Inglese
THE BREAST
22
2
109
120
12
CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT
Internazionale
Sì, ma tipo non specificato
sì
23462680
WOS:000317634900002
2-s2.0-84875534675
W2023383785
Cell & Developmental Biology contains resources in biochemistry, molecular biology, biophysics, physiology, and pharmacology that have a specific emphasis on cellular function in eukaryotic systems. Topics of particular importance include receptor biology and signal transduction, regulation of gene expression at the cellular level, developmental genetics, developmental biology and morphogenesis, and cell-environment interactions. Resources concentrated on molecular biochemistry and molecular regulation of gene expression, as well as microscopic or histological analysis of cell or tissue samples are excluded.
Medical Research, Organs & Systems includes resources dealing with the normal and disease states of single organs, tissues, or single physiological systems, exclusive of the heart, vascular and immune systems. Systems covered here include hepatology, pulmonary function/physiology, gastroenterology, otolaryngology, respiratory system, andrology, gynecology and reproduction, dermatology, and dentistry/odontology. Resources dealing with general physiology, classes of disease that immediately affect many or all body systems, and medical research focused on specific types of medical intervention are excluded.
The Oncology category covers resources on the etiology, prevention, diagnosis, and treatment of cancer such as chemotherapy, radiation and gene therapy. Cancer specialties such as gynecologic oncology, neuro-oncology, surgical oncology, radiological oncology, oral oncology and dermatological oncology are also included.
http://www.sciencedirect.com/science/article/pii/S0960977613000180
ITALIA
none
Arpino, G; Generali, D; Sapino, A; Lucia del, M; Frassoldati, A; de Laurentis, M; Paolo, P; Mustacchi, G; Cazzaniga, M; De Placido, S; Conte, Pierfran...espandi
01 CONTRIBUTO IN RIVISTA::01.01 - Articolo in rivista
info:eu-repo/semantics/article
19
262
01.01 - Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/2681262
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