BACKGROUND: Aggressive surgery has been suggested for improving local tumor control in patients with retroperitoneal sarcoma (RS). This study aimed at investigating local disease-free and overall survival after complete surgery, in patients with RS. PATIENTS AND METHODS: Retrospective data of patients submitted to complete surgery for RS were extracted from a prospectively-maintained database. RESULTS: Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%). Patients presenting with recurrent (hazard ratio (HR)=5.57, p=0.002) and high-grade (HR 3.47, p=0.041) tumors were at higher risk of local recurrence. Microscopically-involved tumor resection margins (HR=3.47, p=0.04) and recurrent tumor at presentation (HR=2.49, p=0.008) were independent predictors of poor survival. CONCLUSION: Patients presenting with primary RS had longer local disease-free survival and overall survival than those with recurrent tumor after complete surgery. Complete surgery remains the standard-of-care for patients with primary RS.

Patient outcome after complete surgery for retroperitoneal sarcoma.

ROSSI, CARLO RICCARDO;VAROTTO, ANDREA;PASQUALI, SANDRO;CAMPANA, LUCA GIOVANNI;MOCELLIN, SIMONE;SOMMARIVA, ANTONIO;RASTRELLI, MARCO;VECCHIATO, ANTONELLA;NITTI, DONATO
2013

Abstract

BACKGROUND: Aggressive surgery has been suggested for improving local tumor control in patients with retroperitoneal sarcoma (RS). This study aimed at investigating local disease-free and overall survival after complete surgery, in patients with RS. PATIENTS AND METHODS: Retrospective data of patients submitted to complete surgery for RS were extracted from a prospectively-maintained database. RESULTS: Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%). Patients presenting with recurrent (hazard ratio (HR)=5.57, p=0.002) and high-grade (HR 3.47, p=0.041) tumors were at higher risk of local recurrence. Microscopically-involved tumor resection margins (HR=3.47, p=0.04) and recurrent tumor at presentation (HR=2.49, p=0.008) were independent predictors of poor survival. CONCLUSION: Patients presenting with primary RS had longer local disease-free survival and overall survival than those with recurrent tumor after complete surgery. Complete surgery remains the standard-of-care for patients with primary RS.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2837140
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