Usefulness of radioiodinated fibrinogen in tumour localization and control of coagulation process in patients with osteosarcoma was evaluated. Tumour external detection demonstrated positive localization in all cases of osteosarcoma before any treatment and in 2 cases of relapse of the disease 4-6 months after the radiation therapy. Patients with osteosarcoma showed fibrinogen half-life, survival and turnover significantly faster than control subjects. FDP levels were correlated to half-life lowering. Heparin therapy corrected into normal range fibrinogen half-life in 3 patients treated. These results suggest that the alteration of fibrinogen metabolism depends on the presence of osteosarcoma and on the concentration of this agent in cancer tissues and propose radioiodinated fibrinogen as a diagnostic agent in clinical staging and follow-up of the patients suffering from osteosarcoma. © 1980.
Radioiodinated fibrinogen in the evaluation of patients with osteosarcoma.
PENGO, VITTORIO;
1980
Abstract
Usefulness of radioiodinated fibrinogen in tumour localization and control of coagulation process in patients with osteosarcoma was evaluated. Tumour external detection demonstrated positive localization in all cases of osteosarcoma before any treatment and in 2 cases of relapse of the disease 4-6 months after the radiation therapy. Patients with osteosarcoma showed fibrinogen half-life, survival and turnover significantly faster than control subjects. FDP levels were correlated to half-life lowering. Heparin therapy corrected into normal range fibrinogen half-life in 3 patients treated. These results suggest that the alteration of fibrinogen metabolism depends on the presence of osteosarcoma and on the concentration of this agent in cancer tissues and propose radioiodinated fibrinogen as a diagnostic agent in clinical staging and follow-up of the patients suffering from osteosarcoma. © 1980.
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