Objectives: To ascertain the prognostic role of endoglin (CD105)-assessed microvessel density (MVD) in patients older than 65 years with laryngeal squamous cell carcinoma (LSCC), and whether this MVD differed in the elderly patients from younger adult controls. Design: Retrospective clinicopathologic investigation. Setting: Academic tertiary referral center. Patients: Fifty-seven consecutive elderly patients with LSCC and 19 younger adult controls. Main Outcome Measure: Image analysis of immunohistochemical reactions. Results: In LSCCs in elderly patients, N+ stage correlated with a shorter disease-free survival (DFS) (P<.001). A higher CD105-assessed MVD was associated with disease recurrence (P=.006). The DFS was shorter in elderly patients whose CD105 expression was greater than 9.6% than in patients whose CD105 expression was 9.6% or less (P=.001). Among the elderly patients with tumors staged as N0, a higher CD105-assessed MVD correlated with disease recurrence (P=.006) and a shorter DFS (P=.001). CD105-assessed MVD in LSCC occurring in elderly patients did not differ from the situation observed in younger adult controls (P=.74). Conclusions: In LSCC occurring in elderly patients, CD105-assessed MVD may be a useful N-stage independent, angiogenic prognostic marker for pinpointing: (1) patients at higher risk of disease recurrence; and (2) patients with N0 tumors at higher risk of early recurrence, who may benefit from more aggressive therapy.

A Higher CD105-Assessed Microvessel Density and Worse Prognosis in Elderly Patients With Laryngeal Carcinoma

MARIONI, GINO;STAFFIERI, ALBERTO;MANZATO, ENZO;LIONELLO, MARCO;PROSENIKLIEV, VLATKO;Marchese Ragona R;BOLZETTA, FRANCESCO;BLANDAMURA, STELLA
2011

Abstract

Objectives: To ascertain the prognostic role of endoglin (CD105)-assessed microvessel density (MVD) in patients older than 65 years with laryngeal squamous cell carcinoma (LSCC), and whether this MVD differed in the elderly patients from younger adult controls. Design: Retrospective clinicopathologic investigation. Setting: Academic tertiary referral center. Patients: Fifty-seven consecutive elderly patients with LSCC and 19 younger adult controls. Main Outcome Measure: Image analysis of immunohistochemical reactions. Results: In LSCCs in elderly patients, N+ stage correlated with a shorter disease-free survival (DFS) (P<.001). A higher CD105-assessed MVD was associated with disease recurrence (P=.006). The DFS was shorter in elderly patients whose CD105 expression was greater than 9.6% than in patients whose CD105 expression was 9.6% or less (P=.001). Among the elderly patients with tumors staged as N0, a higher CD105-assessed MVD correlated with disease recurrence (P=.006) and a shorter DFS (P=.001). CD105-assessed MVD in LSCC occurring in elderly patients did not differ from the situation observed in younger adult controls (P=.74). Conclusions: In LSCC occurring in elderly patients, CD105-assessed MVD may be a useful N-stage independent, angiogenic prognostic marker for pinpointing: (1) patients at higher risk of disease recurrence; and (2) patients with N0 tumors at higher risk of early recurrence, who may benefit from more aggressive therapy.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/2840359
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