Major depressive disorder (MDD) is associated with alterations in multiple brain networks including the default mode network (DMN). The DMN is a set of large-scale connected brain regions that oscillate synchronously and are more active during rest relative to goal-directed tasks. Several functions have been hypothesized for the DMN, including cognitive, self-referential and social functions. Widespread alterations in the core and the subsystems of the DMN as well as in their interplay have been reported in MDD. We will review the evidence supporting DMN alterations in patients with MDD and underscore how they can contribute to social and affective cognitive impairments in this disorder. © 2013 Giovanni Fioriti Editore s.r.l.
Default mode network in depression: A pathway to impaired affective cognition?
Sambataro F.;GIUSTI, PIETRO;
2013
Abstract
Major depressive disorder (MDD) is associated with alterations in multiple brain networks including the default mode network (DMN). The DMN is a set of large-scale connected brain regions that oscillate synchronously and are more active during rest relative to goal-directed tasks. Several functions have been hypothesized for the DMN, including cognitive, self-referential and social functions. Widespread alterations in the core and the subsystems of the DMN as well as in their interplay have been reported in MDD. We will review the evidence supporting DMN alterations in patients with MDD and underscore how they can contribute to social and affective cognitive impairments in this disorder. © 2013 Giovanni Fioriti Editore s.r.l.Pubblicazioni consigliate
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