Articular cartilage lesions are a particular challenge for regenerative medicine due to cartilage low self-ability repair in case of damage. Hence, a significant goal of musculoskeletal tissue engineering is the development of suitable structures in virtue of their matrix composition and biomechanical properties. The objective of our study was to design in vitro a supporting structure for autologous chondrocyte growth. We realized a biohybrid composite scaffold combining a novel and nonspecific extracellular matrix (ECM), which is decellularizedWharton’s jelly ECM, with the biomechanical properties of the synthetic hydrogel polyvinyl alcohol (PVA).Wharton’s jelly ECMwas tested for its ability in promoting scaffold colonization by chondrocytes and compared with polyvinyl alcohol itself and the more specific decellularized cartilage matrix. Our preliminary evidences highlighted the chance of usingWharton’s jelly ECMin combinationwith PVAhydrogels as an innovative and easily available scaffold for cartilage restoration.

Tailored PVA/ECM Scaffolds for Cartilage Regeneration

STOCCO, ELENA;BARBON, SILVIA;DALZOPPO, DANIELE;FOLIN, MARCELLA;PARNIGOTTO, PIER PAOLO;GRANDI, CLAUDIO
2014

Abstract

Articular cartilage lesions are a particular challenge for regenerative medicine due to cartilage low self-ability repair in case of damage. Hence, a significant goal of musculoskeletal tissue engineering is the development of suitable structures in virtue of their matrix composition and biomechanical properties. The objective of our study was to design in vitro a supporting structure for autologous chondrocyte growth. We realized a biohybrid composite scaffold combining a novel and nonspecific extracellular matrix (ECM), which is decellularizedWharton’s jelly ECM, with the biomechanical properties of the synthetic hydrogel polyvinyl alcohol (PVA).Wharton’s jelly ECMwas tested for its ability in promoting scaffold colonization by chondrocytes and compared with polyvinyl alcohol itself and the more specific decellularized cartilage matrix. Our preliminary evidences highlighted the chance of usingWharton’s jelly ECMin combinationwith PVAhydrogels as an innovative and easily available scaffold for cartilage restoration.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3032300
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