The effects of enrofloxacin (EFX) on reproduction, survival and growth were evaluated in a two-generations study on Daphnia magna. In F0, lethality (EC50 9.78 mg L-1), even if less sensitive than the reproduction inhibition endpoint (EC50 6.49 mg L-1), was prevalent at high concentrations, preventing observation of the reproduction-inhibition plateau. Lowest LOEC for reproduction inhibition (3.13 mg L-1) was obtained in re-exposed F1. However, effects on reproduction (LOEC 6.25 mg L-1) were also observed in non-exposed F1 born to exposed F0, highlighting the reverberation of toxic effects of EFX along D. magna generations. Thus, It was concluded that multigenerational studies may detect otherwise unnoticed effects that could be relevant for the environmental equilibrium.
EFFETTI TOSSICI DELL’ENROFLOXACINA SU DAPHNIA MAGNA, STUDIO CON DUE GENERAZIONI
DALLA BONA, MIRCO;MERLANTI, ROBERTA;DE LIGUORO, MARCO
2012
Abstract
The effects of enrofloxacin (EFX) on reproduction, survival and growth were evaluated in a two-generations study on Daphnia magna. In F0, lethality (EC50 9.78 mg L-1), even if less sensitive than the reproduction inhibition endpoint (EC50 6.49 mg L-1), was prevalent at high concentrations, preventing observation of the reproduction-inhibition plateau. Lowest LOEC for reproduction inhibition (3.13 mg L-1) was obtained in re-exposed F1. However, effects on reproduction (LOEC 6.25 mg L-1) were also observed in non-exposed F1 born to exposed F0, highlighting the reverberation of toxic effects of EFX along D. magna generations. Thus, It was concluded that multigenerational studies may detect otherwise unnoticed effects that could be relevant for the environmental equilibrium.
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