Post-Radiation Sarcomas

Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation field at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Wide resection with limb salvage or amputation is recommended for improved local control. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.