Osteoporosis is the most common non-traumatic skeletal disorder, which weakens bone and increases the fracture risk. Hypoestrogenic status of menopause accelerate the age-related bone loss, leading to increased risk of osteoporosis development, but the responsibility of each variable in conditioning bone mass alteration is unclear. The aim of this study was to investigate the relationship between some bone turnover markers, such as alkaline phosphatase (ALP), osteocalcin and PTH, BMD and circulating 17-β- estradiol (e2) in recently menopausal women. Patients & Methods: A group of 21 postmenopausal women (median age 52 years, range 49–54 years) were enrolled in the study. All patients underwent lumbar spine (LS) BMD measurement by DXA. The coefficient of variation was <1 %. ALP, osteocalcin, PTH, and e2 serum levels were also measured. Patients with severe renal or hepatic impairment or major cardiovascular diseases were excluded from this study. Results: The mean ALP, osteocalcin, PTH, and e2 serum levels were 141.1±13.8 U/L, 4.2±1.3 ng/mL, 67.1±1.3 ng/mL, and 99.7±15.8 pmol/L, respectively. As expected, an inverse correlation between age and both LS-BMD (R=0.50, p=0.021) and e2 (R=0.89, p=0.00001) was found. No correlation between ALP and age (R=0.40, p=0.06), e2 (R=0.35, p=0.12), LS-BMD (R=0.30, p=0.19), PTH (R=0.13, p=0.54) and osteocalcin (R=0.05, p=0.99). There was a weak inverse relationship between LS-BMD and osteocalcin (R=0.40, p=0.07), but a significant relationship between e2 and both BMD (R=0.52, p=0.014) and osteocalcin (R=0.0.46, p=0.038). At multivariate analysis, only age and e2 were independent predictors of LS-BMD changes. Conclusion: Our study suggests that, in recently menopausal women, hormonal status as defined by e2 and partially by osteocalcin represents useful predictors of bone loss.

Relationship between bone turnover marker, bone density and serum estrogen levels in recently menopausal women

CAMOZZI, VALENTINA;LUMACHI, FRANCO
2015

Abstract

Osteoporosis is the most common non-traumatic skeletal disorder, which weakens bone and increases the fracture risk. Hypoestrogenic status of menopause accelerate the age-related bone loss, leading to increased risk of osteoporosis development, but the responsibility of each variable in conditioning bone mass alteration is unclear. The aim of this study was to investigate the relationship between some bone turnover markers, such as alkaline phosphatase (ALP), osteocalcin and PTH, BMD and circulating 17-β- estradiol (e2) in recently menopausal women. Patients & Methods: A group of 21 postmenopausal women (median age 52 years, range 49–54 years) were enrolled in the study. All patients underwent lumbar spine (LS) BMD measurement by DXA. The coefficient of variation was <1 %. ALP, osteocalcin, PTH, and e2 serum levels were also measured. Patients with severe renal or hepatic impairment or major cardiovascular diseases were excluded from this study. Results: The mean ALP, osteocalcin, PTH, and e2 serum levels were 141.1±13.8 U/L, 4.2±1.3 ng/mL, 67.1±1.3 ng/mL, and 99.7±15.8 pmol/L, respectively. As expected, an inverse correlation between age and both LS-BMD (R=0.50, p=0.021) and e2 (R=0.89, p=0.00001) was found. No correlation between ALP and age (R=0.40, p=0.06), e2 (R=0.35, p=0.12), LS-BMD (R=0.30, p=0.19), PTH (R=0.13, p=0.54) and osteocalcin (R=0.05, p=0.99). There was a weak inverse relationship between LS-BMD and osteocalcin (R=0.40, p=0.07), but a significant relationship between e2 and both BMD (R=0.52, p=0.014) and osteocalcin (R=0.0.46, p=0.038). At multivariate analysis, only age and e2 were independent predictors of LS-BMD changes. Conclusion: Our study suggests that, in recently menopausal women, hormonal status as defined by e2 and partially by osteocalcin represents useful predictors of bone loss.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3167789
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