The G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. In addition, a polymorphism (rs2274911, Pro91Ser) in GPRC6A is associated with prostate cancer, a typical androgen-sensitive cancer.
Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure
DE TONI, LUCA;DI NISIO, ANDREA;SPELTRA, ELENA;ROCCA, MARIA SANTA;GHEZZI, MARCO;ZUCCARELLO, DANIELA;FERLIN, ALBERTO;FORESTA, CARLO
2016
Abstract
The G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. In addition, a polymorphism (rs2274911, Pro91Ser) in GPRC6A is associated with prostate cancer, a typical androgen-sensitive cancer.File in questo prodotto:
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