Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

Ley, Timothy; Miller, Christopher; Ding, Li; Raphael, Benjamin J.; Mungall, Andrew J.; Robertson, A. Gordon; Hoadley, Katherine; Triche, Timothy J.; Laird, Peter W.; Baty, Jack D.; Fulton, Lucinda L.; Fulton, Robert; Heath, Sharon E.; Kalicki Veizer, Joelle; Kandoth, Cyriac; Klco, Jeffery M.; Koboldt, Daniel C.; Kanchi, Krishna Latha; Kulkarni, Shashikant; M. S., P. h. D.; F. A. C. M. G.,; Lamprecht, Tamara L.; B. S.,; University, Washington; Louis, S. t.; Larson, David E.; P. h. D.,; Lin, Ling; M. S.,; Charles, Lu; P. h. D.,; Mclellan, Michael D.; B. S.,; Mcmichael, Joshua F.; B. S.,; the Genome Institute at Washington University,; Louis, S. t.; Payton, Jacqueline; M. D., P. h. D.; University, Washington; Louis, S. t.; Schmidt, Heather; B. S.,; the Genome Institute at Washington University,; Louis, S. t.; Spencer, David H.; M. D., P. h. D.; University, Washington; Louis, S. t.; Tomasson, Michael H.; M. D.,; University, Washington; Siteman Cancer Center, S. t. Louis; Wallis, John W.; P. h. D.,; the Genome Institute at Washington University,; Louis, S. t.; Wartman, Lukas D.; M. D.,; Watson, Mark A.; M. D., P. h. D.; Welch, John; M. D., P. h. D.; University, Washington; Louis, S. t.; Wendl, Michael C.; P. h. D.,; the Genome Institute at Washington University,; Louis, S. t.; Ally, Adrian; B. S. c.,; Balasundaram, Miruna; B. A. S. c.,; Birol, Inanc; P. h. D.,; Butterfield, Yaron; B. S. c.,; Chiu, Readman; M. S. c.,; Chu, Andy; B. S. c.,; Chuah, Eric; B. S. c.,; Hye Jung Chun,; M. S. c.,; Corbett, Richard; M. S. c.,; Dhalla, Noreen; B. S. c.,; Guin, Ranabir; B. A. S. c.,; He, An; M. S. c.,; Hirst, Carrie; B. S. c.,; Hirst, Martin; P. h. D.,; Holt, Robert A.; P. h. D.,; Jones, Steven; P. h. D.,; Karsan, Aly; M. D.,; Lee, Darlene; Haiyan I., Li; M. S. c.,; Marra, Marco A.; P. h. D.,; Mayo, Michael; B. S. c.,; Moore, Richard A.; P. h. D.,; Mungall, Karen; B. S. c.,; Parker, Jeremy; P. h. D.,; Pleasance, Erin; P. h. D.,; Plettner, Patrick; B. S. c.,; Schein, Jacquie; M. S. c.,; Stoll, Dominik; P. h. D.,; Swanson, Lucas; M. S. c.,; Tam, Angela; B. S. c.,; Thiessen, Nina; M. S.,; Varhol, Richard; M. S. c.,; Wye, Natasja; B. S. c.,; Zhao, Yongjun; M. S. c., D. V. M.; British Columbia Cancer Agency's Genome Sciences Centre,; Vancouver, Canada; Gabriel, Stacey; P. h. D.,; Getz, Gad; P. h. D.,; Sougnez, Carrie; B. S.,; Zou, Lihua; P. h. D.,; Broad Institute of Harvard,; Massachusetts Institute of Technology,; Cambridge, Ma; Mark D. M. Leiserson, B. A.; Vandin, Fabio; Hsin Ta Wu,; M. S. c.,; University, Brown; Center for Computational Molecular Biology,; Providence, Ri; Applebaum, Frederick; M. D.,; Fred Hutchinson Cancer Research Center,; Division of Medical Oncology,; Seattle Cancer Care Alliance,; Seattle,; Baylin, Stephen B.; M. D.,; Johns Hopkins University,; Baltimore,; Akbani, Rehan; P. h. D.,; Broom, Bradley M.; P. h. D.,; Chen, Ken; P. h. D.,; Motter, Thomas C.; B. A.,; Nguyen, Khanh; M. D.,; Weinstein, John N.; M. D., P. h. D.; Zhang, Nianziang; P. h. D.,; Anderson Cancer Center, University of Texas M. D.; Houston,; Ferguson, Martin L.; P. h. D.,; Consulting, Mlf; Biotechnology Consultant, Boston; Adams, Christopher; B. S.,; Black, Aaron; B. A.,; Bowen, Jay; M. S.,; Julie Gastier Foster,; P. h. D.,; Grossman, Thomas; M. D., P. h. D.; Lichtenberg, Tara; B. A.,; Wise, Lisa; the Research Institute at Nationwide Children's Hospital,; Columbus, Oh; Davidsen, Tanja; P. h. D.,; Demchok, John A.; M. S.,; Mills Shaw, Kenna R.; P. h. D.,; Sheth, Margi; B. S.,; National Cancer Institute,; Bethesda, Md; Sofia, Heidi J.; P. h. D., M. P. H.; National Human Genome Research Institute,; Bethesda, Md; Yang, Liming; P. h. D.,; National Cancer Institute,; Bethesda, Md; Downing, James R.; M. D.,; Jude Children's Research Hospital, S. t.; Memphis,; Eley, Greg; P. h. D.,; Llc, Sciementis; Statham, Ga; Alonso, Shelley; Ayala, Brenda; B. S. c.,; Baboud, Julien; M. S.,; Backus, Mark; P. h. D.,; Barletta, Sean P.; B. S.,; Berton, Dominique L.; M. S. C. S.,; Chu, Anna L.; B. S. c.,; Girshik, Stanley; M. S.,; Jensen, Mark A.; P. h. D.,; Kahn, Ari; P. h. D.,; Kothiyal, Prachi; P. h. D.,; Nicholls, Matthew C.; M. S.,; Pihl, Todd D.; P. h. D.,; Pot, David A.; P. h. D.,; Raman, Rohini; B. E.,; Sanbhadti, Rashmi N.; B. S.,; Snyder, Eric E.; P. h. D.,; Srinivasan, Deepak; M. S.,; Walton, Jessica; M. S.,; Wan, Yunhu; P. h. D.,; Wang, Zhining; P. h. D.,; International, Sra; Fairfax, Va; Issa, Jean Pierre J.; M. D.,; University, Temple; Philadelphia,; Michelle Le Beau,; P. h. D.,; University of Chicago,; Chicago,; Carroll, Martin; M. D.,; University of Pennsylvania,; Philadelphia,; Hagop Kantarjian, M. D.; Kornblau, Steven; M. D.,; Anderson Cancer Center, University of Texas M. D.; Houston,; Bootwalla, Moiz S.; B. S. c., M. S.; M. S. c.,; Lai, Phillip H.; B. S. c.,; Shen, Hui; B. S. c.,; Van Den Berg, David J.; P. h. D.,; Weisenberger, Daniel J.; P. h. D.,; University of Southern California,; Center, Epigenome; Angeles, Los; Daniel C. Link, M. D.; Walter, Matthew J.; M. D.,; University, Washington; Siteman Cancer Center, S. t. Louis; Ozenberger, Bradley A.; P. h. D.,; National Human Genome Research Institute,; Bethesda, Md; Mardis, Elaine R.; P. h. D.,; the Genome Institute at Washington University,; Louis, S. t.; Westervelt, Peter; M. D., P. h. D.; Graubert, Timothy A.; M. D.,; Dipersio, John F.; M. D., P. h. D.; University, Washington; Siteman Cancer Center, S. t. Louis; Wilson, Richard K.

doi:10.1056/NEJMoa1301689

Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

Ley, Timothy;Miller, Christopher;Ding, Li;Raphael, Benjamin J.;Mungall, Andrew J.;Robertson, A. Gordon;Hoadley, Katherine;Triche, Timothy J.;Laird, Peter W.;Baty, Jack D.;Fulton, Lucinda L.;Fulton, Robert;Heath, Sharon E.;Kalicki Veizer, Joelle;Kandoth, Cyriac;Klco, Jeffery M.;Koboldt, Daniel C.;Kanchi, Krishna Latha;Shashikant Kulkarni;M. S. , P.h. D.;F. A. C. M. G.;Tamara L. Lamprecht;B. S.;Washington University;S.t. Louis;David E. Larson;P.h. D.;Ling Lin;M. S.;Charles Lu;P.h. D.;Michael D. McLellan;B. S.;Joshua F. McMichael;B. S.;S.t. Louis;Jacqueline Payton;M. D. , P.h. D.;Washington University;S.t. Louis;Heather Schmidt;B. S.;S.t. Louis;David H. Spencer;M. D. , P.h. D.;Washington University;S.t. Louis;Michael H. Tomasson;M. D.;Washington University;Siteman Cancer Center, S.t. Louis;John W. Wallis;P.h. D.;S.t. Louis;Lukas D. Wartman;M. D.;Mark A. Watson;M. D. , P.h. D.;John Welch;M. D. , P.h. D.;Washington University;S.t. Louis;Michael C. Wendl;P.h. D.;S.t. Louis;Adrian Ally;B. S.c.;Miruna Balasundaram;B. A. S.c.;Inanc Birol;P.h. D.;Yaron Butterfield;B. S.c.;Readman Chiu;M. S.c.;Andy Chu;B. S.c.;Eric Chuah;B. S.c.;Hye Jung Chun;M. S.c.;Richard Corbett;M. S.c.;Noreen Dhalla;B. S.c.;Ranabir Guin;B. A. S.c.;An He;M. S.c.;Carrie Hirst;B. S.c.;Martin Hirst;P.h. D.;Robert A. Holt;P.h. D.;Steven Jones;P.h. D.;Aly Karsan;M. D.;Darlene Lee;Haiyan I. Li;M. S.c.;Marco A. Marra;P.h. D.;Michael Mayo;B. S.c.;Richard A. Moore;P.h. D.;Karen Mungall;B. S.c.;Jeremy Parker;P.h. D.;Erin Pleasance;P.h. D.;Patrick Plettner;B. S.c.;Jacquie Schein;M. S.c.;Dominik Stoll;P.h. D.;Lucas Swanson;M. S.c.;Angela Tam;B. S.c.;Nina Thiessen;M. S.;Richard Varhol;M. S.c.;Natasja Wye;B. S.c.;Yongjun Zhao;M. S.c. , D. V. M.;Vancouver, Canada;Stacey Gabriel;P.h. D.;Gad Getz;P.h. D.;Carrie Sougnez;B. S.;Lihua Zou;P.h. D.;Broad Institute of Harvard;Massachusetts Institute of Technology;Cambridge, MA;Mark D. M. Leiserson, B. A.;VANDIN, FABIO;Hsin Ta Wu;M. S.c.;Brown University;Providence, RI;Frederick Applebaum;M. D.;Fred Hutchinson Cancer Research Center;Division of Medical Oncology;Seattle Cancer Care Alliance;Seattle;Stephen B. Baylin;M. D.;Johns Hopkins University;Baltimore;Rehan Akbani;P.h. D.;Bradley M. Broom;P.h. D.;Ken Chen;P.h. D.;Thomas C. Motter;B. A.;Khanh Nguyen;M. D.;John N. Weinstein;M. D. , P.h. D.;Nianziang Zhang;P.h. D.;Houston;Martin L. Ferguson;P.h. D.;MLF Consulting;Biotechnology Consultant, Boston;Christopher Adams;B. S.;Aaron Black;B. A.;Jay Bowen;M. S.;Julie Gastier Foster;P.h. D.;Thomas Grossman;M. D. , P.h. D.;Tara Lichtenberg;B. A.;Lisa Wise;Columbus, OH;Tanja Davidsen;P.h. D.;John A. Demchok;M. S.;Kenna R. Mills Shaw;P.h. D.;Margi Sheth;B. S.;National Cancer Institute;Bethesda, MD;Heidi J. Sofia;P.h. D. , M. P. H.;Bethesda, MD;Liming Yang;P.h. D.;National Cancer Institute;Bethesda, MD;James R. Downing;M. D.;S.t. Jude Children's Research Hospital;Memphis;Greg Eley;P.h. D.;Sciementis LLC;Statham, GA;Shelley Alonso;Brenda Ayala;B. S.c.;Julien Baboud;M. S.;Mark Backus;P.h. D.;Sean P. Barletta;B. S.;Dominique L. Berton;M. S. C. S.;Anna L. Chu;B. S.c.;Stanley Girshik;M. S.;Mark A. Jensen;P.h. D.;Ari Kahn;P.h. D.;Prachi Kothiyal;P.h. D.;Matthew C. Nicholls;M. S.;Todd D. Pihl;P.h. D.;David A. Pot;P.h. D.;Rohini Raman;B. E.;Rashmi N. Sanbhadti;B. S.;Eric E. Snyder;P.h. D.;Deepak Srinivasan;M. S.;Jessica Walton;M. S.;Yunhu Wan;P.h. D.;Zhining Wang;P.h. D.;SRA International;Fairfax, VA;Jean Pierre J. Issa;M. D.;Temple University;Philadelphia;Michelle Le Beau;P.h. D.;University of Chicago;Chicago;Martin Carroll;M. D.;University of Pennsylvania;Philadelphia;Hagop Kantarjian, M. D.;Steven Kornblau;M. D.;Houston;Moiz S. Bootwalla;B. S.c. , M. S.;M. S.c.;Phillip H. Lai;B. S.c.;Hui Shen;B. S.c.;David J. Van Den Berg;P.h. D.;Daniel J. Weisenberger;P.h. D.;University of Southern California;Epigenome Center;Los Angeles;Daniel C. Link, M. D.;Matthew J. Walter;M. D.;Washington University;Siteman Cancer Center, S.t. Louis;Bradley A. Ozenberger;P.h. D.;Bethesda, MD;Elaine R. Mardis;P.h. D.;S.t. Louis;Peter Westervelt;M. D. , P.h. D.;Timothy A. Graubert;M. D.;John F. DiPersio;M. D. , P.h. D.;Washington University;Siteman Cancer Center, S.t. Louis;Richard K. Wilson

2013

Abstract

Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.

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	Anno
	
			2013
		
	Rivista su cui è pubblicata l'opera
	
			NEW ENGLAND JOURNAL OF MEDICINE
		
	Codice DOI
	
			https://dx.doi.org/10.1056/NEJMoa1301689
		
	Codice WOS
	
			WOS:000319574200004
		
	Codice Scopus
	
			2-s2.0-84878372012
		
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			01.01 - Articolo in rivista

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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3194446

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

2013

Abstract

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