Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(beta-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(beta-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery
FRASCONI, MARCO;
2015
Abstract
Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(beta-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(beta-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
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Nanoscale 2015 7 7178-7183.pdf
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