Background: Osteoporosis is relatively rare among men, but represents one of the leading causes of morbidity and mortality among elderly men. The precocious recognition of patients at increased risk of fracture is still a challenge for physicians. In this preliminary study we evaluated the relationship between bone mineral density (BMD), parathyroid hormone (PTH), 25-Hydroxyvitamin D [25(OH)D] and insulin-like growth factor-1 (IGF-1) serum levels in a group of osteoporotic men (≥65 years old). Patients and Methods: A group of 15 elderly men (median age 68 years, range 65-74 years) with confirmed osteoporosis (LS T-score below ‒2SD) underwent PTH, 25(OH)D and IGF-1 serum levels measurement. As previously reported, PTH was analyzed by an immunometric assay (Intact PTH Bridge, Adaltis, Bologna, Italy) with a detection limit 10 pg/mL and inter- and intra-assay CV of 4% and 3.5%, respectively. 25(OH)D was determined by a radioimmunoassay (RIA) (25-hydroxyvitamin D 125I RIA kit, DiaSorin, Stillwater, MN, USA), detection limit 5 nmol/L and inter- and intra-assay CV of 9%. Serum IGF-I was measured by a immunoradiometric method (IGF-1 kit, Immunotech, Marseille, France) with detection limit 10 ng/mL and inter- and intra-assay CV of 11% and 4%, respectively. The evaluation of lumbar spine (LS) bone mineral density (BMD) was obtained with dual-energy X-ray absorptiometry (DXA) in all patients. Results: The results were the following: LS-BMD=0.777±0.060 g/cm2, PTH=75.2±8.3 pg/mL, 25(OH)D=365.1±134.4 nmol/L, IGF-1=201.3±55.3 ng/mL. No correlation was found between age and LS-BMD (R=‒0.034, p=0.91), PTH (R=0.276, p=0.31), 25(OH)D (R=‒0.235, p=0.40), IGF-1 (R=0.219, p=0.43). No correlation between 25(OH)D and BMD (R=0.278, p=0.32), PTH (R=0.036, p=0.88), IGF-1 (R=0.032, p=0.91), and between IGF-1 and PTH (R=0.292, p=0.29). There was e significant inverse relationship between BMD and both PTH (R=‒0.511, p=0.047) and IGF-1 (R=‒0.662, p=0.007).
Relationship between bone mineral density, PTH, 25(OH)D and IGF-1 serum levels in elderly men with osteoporosis: results from a preliminary study
LUMACHI, FRANCO;CAMOZZI, VALENTINA;
2016
Abstract
Background: Osteoporosis is relatively rare among men, but represents one of the leading causes of morbidity and mortality among elderly men. The precocious recognition of patients at increased risk of fracture is still a challenge for physicians. In this preliminary study we evaluated the relationship between bone mineral density (BMD), parathyroid hormone (PTH), 25-Hydroxyvitamin D [25(OH)D] and insulin-like growth factor-1 (IGF-1) serum levels in a group of osteoporotic men (≥65 years old). Patients and Methods: A group of 15 elderly men (median age 68 years, range 65-74 years) with confirmed osteoporosis (LS T-score below ‒2SD) underwent PTH, 25(OH)D and IGF-1 serum levels measurement. As previously reported, PTH was analyzed by an immunometric assay (Intact PTH Bridge, Adaltis, Bologna, Italy) with a detection limit 10 pg/mL and inter- and intra-assay CV of 4% and 3.5%, respectively. 25(OH)D was determined by a radioimmunoassay (RIA) (25-hydroxyvitamin D 125I RIA kit, DiaSorin, Stillwater, MN, USA), detection limit 5 nmol/L and inter- and intra-assay CV of 9%. Serum IGF-I was measured by a immunoradiometric method (IGF-1 kit, Immunotech, Marseille, France) with detection limit 10 ng/mL and inter- and intra-assay CV of 11% and 4%, respectively. The evaluation of lumbar spine (LS) bone mineral density (BMD) was obtained with dual-energy X-ray absorptiometry (DXA) in all patients. Results: The results were the following: LS-BMD=0.777±0.060 g/cm2, PTH=75.2±8.3 pg/mL, 25(OH)D=365.1±134.4 nmol/L, IGF-1=201.3±55.3 ng/mL. No correlation was found between age and LS-BMD (R=‒0.034, p=0.91), PTH (R=0.276, p=0.31), 25(OH)D (R=‒0.235, p=0.40), IGF-1 (R=0.219, p=0.43). No correlation between 25(OH)D and BMD (R=0.278, p=0.32), PTH (R=0.036, p=0.88), IGF-1 (R=0.032, p=0.91), and between IGF-1 and PTH (R=0.292, p=0.29). There was e significant inverse relationship between BMD and both PTH (R=‒0.511, p=0.047) and IGF-1 (R=‒0.662, p=0.007).
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
