Background: Left atrial (LA) size and function are well-known predictors of cardiovascular outcome. Our aim was to evaluate age-related changes in LA volumes and function in healthy subjects using a novel prototype 3D software dedicated for atrium quantitation. Methods: 65 healthy volunteers aged 18 to 65 (38+12 years, 34 men) and good acoustic window underwent 3D LA full-volume acquisition from apical approach (31+6 vps). LA data sets were analyzed with a semi-automated software (TomTec, Unterschleissheim, D). LA volumes (LAV max; min; preA = LAV before LA contraction) and LA function indexes were provided. Results: LA indexes derived from a single 3D LA data set analysis (average time 4′10′′) are summarized in Table. Age was positively correlated with all LA volumes (LAV max r=0.32, min r=0.30, preA r=0.42, p,0.02 for all). Both active and total LA ejection fraction were marginally correlated with age (r=-0.24 and r=0.24, p=0.05 for both). LA active stroke volume increased with ageing (r=0.43, p,0.001), the active LA contribution ranging from 26+8% of total LA stroke volume in subjects ,30 years to 35+10% in subjects .50 years (p ANOVA=0.02). Conversely, LA total stroke volume or LA sphericity were not age-related. Intraclass correlation coefficients for LAV max, min and preA were 0.98, 0.93, 0.94 for intraobserver and 0.82, 0.66, 0.80 for interobserver reproducibility, respectively. Conclusions: The tested software dedicated for LA quantitation on 3D data sets works fairly rapid and reproducible, enabling the detection of age-related changes in LA size and function. Reference values are provided for clinical testing of this new LA software

Effect of ageing on left atrial geometry and function assessed by three-dimensional echocardiography

MURARU, DENISA;PELUSO, DILETTA MARIA;CUCCHINI, UMBERTO;AL MAMARY, AHMED HUSSIEN HUSSIEN;BADANO, LUIGI;ILICETO, SABINO
2011

Abstract

Background: Left atrial (LA) size and function are well-known predictors of cardiovascular outcome. Our aim was to evaluate age-related changes in LA volumes and function in healthy subjects using a novel prototype 3D software dedicated for atrium quantitation. Methods: 65 healthy volunteers aged 18 to 65 (38+12 years, 34 men) and good acoustic window underwent 3D LA full-volume acquisition from apical approach (31+6 vps). LA data sets were analyzed with a semi-automated software (TomTec, Unterschleissheim, D). LA volumes (LAV max; min; preA = LAV before LA contraction) and LA function indexes were provided. Results: LA indexes derived from a single 3D LA data set analysis (average time 4′10′′) are summarized in Table. Age was positively correlated with all LA volumes (LAV max r=0.32, min r=0.30, preA r=0.42, p,0.02 for all). Both active and total LA ejection fraction were marginally correlated with age (r=-0.24 and r=0.24, p=0.05 for both). LA active stroke volume increased with ageing (r=0.43, p,0.001), the active LA contribution ranging from 26+8% of total LA stroke volume in subjects ,30 years to 35+10% in subjects .50 years (p ANOVA=0.02). Conversely, LA total stroke volume or LA sphericity were not age-related. Intraclass correlation coefficients for LAV max, min and preA were 0.98, 0.93, 0.94 for intraobserver and 0.82, 0.66, 0.80 for interobserver reproducibility, respectively. Conclusions: The tested software dedicated for LA quantitation on 3D data sets works fairly rapid and reproducible, enabling the detection of age-related changes in LA size and function. Reference values are provided for clinical testing of this new LA software
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3223731
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