The potent kinesin spindle protein inhibitor CPUYJ039 and a set of analogues were prepared by a targetoriented approach based on a Ugi reaction that uses 2- nitrophenyl isocyanides as key building blocks. The herein documented strategy provides straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploring the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents
MARZARO, GIOVANNI;
2017
Abstract
The potent kinesin spindle protein inhibitor CPUYJ039 and a set of analogues were prepared by a targetoriented approach based on a Ugi reaction that uses 2- nitrophenyl isocyanides as key building blocks. The herein documented strategy provides straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploring the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
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