Silver(I), gold(I), copper(I) and ruthenium(II) N-heterocyclic carbene (NHC) complexes have been synthesised and their cytotoxic activities towards various cancer cell lines have been evaluated. The N-heterocyclic carbene ligand has been functionalised with a 1,2,3-triazole moiety tethered in the backbone of the ligand. The molecular structure of the silver(I) and gold(I) complexes has been solved by X-ray diffraction analysis. The AgI, AuI and RuII complexes display good stability in aqueous conditions and show cytotoxic activities comparable or slightly superior to those of similar unfunctionalised complexes.
Synthesis, Structure and Antitumoural Activity of Triazole-Functionalised NHC-Metal Complexes
MONTICELLI, MARCO;TUBARO, CRISTINA;RANCAN, MARZIO
2017
Abstract
Silver(I), gold(I), copper(I) and ruthenium(II) N-heterocyclic carbene (NHC) complexes have been synthesised and their cytotoxic activities towards various cancer cell lines have been evaluated. The N-heterocyclic carbene ligand has been functionalised with a 1,2,3-triazole moiety tethered in the backbone of the ligand. The molecular structure of the silver(I) and gold(I) complexes has been solved by X-ray diffraction analysis. The AgI, AuI and RuII complexes display good stability in aqueous conditions and show cytotoxic activities comparable or slightly superior to those of similar unfunctionalised complexes.File in questo prodotto:
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