Prostaglandin (PG)E2, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate, white blood cells, total protein, total complement activity, and beta-2-microglobulin, were measured in the synovial fluid (SF) of 16 patients affected with knee-joint effusion due to rheumatoid arthritis at baseline and after seven days. The volume of SF was also calculated. Eight patients were randomly allocated to treatment with priprofen, 800 mg/day, and eight remained without treatment. In the treated patients we found a significant increase in cAMP and a significant decrease in PGE2, while in controls no variations were observed. The other indices did not show significant changes in any of these groups. These data may suggest an anti-inflammatory effect of pirprofen that appears to be mediated by PG-inhibition as well as by the stimulation of cAMP.
The effect of Pirprofen on the prostaglandins and cyclic nucleotides of synovial fluid in rheumatoid arthritis
CALO', LORENZO;R. RAMONDA;
1987
Abstract
Prostaglandin (PG)E2, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate, white blood cells, total protein, total complement activity, and beta-2-microglobulin, were measured in the synovial fluid (SF) of 16 patients affected with knee-joint effusion due to rheumatoid arthritis at baseline and after seven days. The volume of SF was also calculated. Eight patients were randomly allocated to treatment with priprofen, 800 mg/day, and eight remained without treatment. In the treated patients we found a significant increase in cAMP and a significant decrease in PGE2, while in controls no variations were observed. The other indices did not show significant changes in any of these groups. These data may suggest an anti-inflammatory effect of pirprofen that appears to be mediated by PG-inhibition as well as by the stimulation of cAMP.
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