Neuromuscular junction (NMJ) represents the morphofunctional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and amyotrophic lateral sclerosis, display altered NMJ and functional denervation. However, the triggers and the molecular mechanisms underlying the dismantlement of NMJ remain unclear.

Muscle Expression of SOD1G93ATriggers the Dismantlement of Neuromuscular Junction via PKC-Theta

Romanello, Vanina;Sandri, Marco;Rudolf, Rüdiger;Musarò, Antonio
2017

Abstract

Neuromuscular junction (NMJ) represents the morphofunctional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and amyotrophic lateral sclerosis, display altered NMJ and functional denervation. However, the triggers and the molecular mechanisms underlying the dismantlement of NMJ remain unclear.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3267312
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