Knockout (KO) of the mitochondrial Ca2+ uniporter (MCU) in mice abrogates mitochondrial Ca2+ uptake and permeability transition pore (PTP) opening. However, hearts from global MCU-KO mice are not protected from ischemic injury. We aimed to investigate whether adaptive alterations occur in cell death signaling pathways in the hearts of global MCU-KO mice.

Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter

Menazza, Sara;Bernardi, Paolo;
2018

Abstract

Knockout (KO) of the mitochondrial Ca2+ uniporter (MCU) in mice abrogates mitochondrial Ca2+ uptake and permeability transition pore (PTP) opening. However, hearts from global MCU-KO mice are not protected from ischemic injury. We aimed to investigate whether adaptive alterations occur in cell death signaling pathways in the hearts of global MCU-KO mice.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3278740
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