Human papillomaviruses (HPVs) are small viruses with a circular double-stranded DNA genome that specifically infect mucosal and cutaneous stratified squamous epithelia. HPV life cycle is tightly linked to the differentiation program of host epithelial cells. The virus infects proliferating cells of the basal layer of epithelia, probably targeting cells with stemness features, and exploits host replication machinery for viral DNA synthesis. As infected cells differentiate while moving up in the epithelium, viral proteins are synthesized allowing assembly of viral particles and their release with exfoliated epithelial cells. Most HPV infections are cleared within two years; however, in some cases, infection may persist, especially with the so-called high-risk HPV types, which are drivers for malignant transformation. High-risk HPVs, especially HPV16 and HPV18, are the causative agents of virtually all cases of cervical cancer and of a proportion of other ano-genital malignancies and head and neck squamous cell carcinomas.

KDM2B in papillomavirus-related cancer

Elektra Peta;Giulia Masi;Luisa Barzon
2018

Abstract

Human papillomaviruses (HPVs) are small viruses with a circular double-stranded DNA genome that specifically infect mucosal and cutaneous stratified squamous epithelia. HPV life cycle is tightly linked to the differentiation program of host epithelial cells. The virus infects proliferating cells of the basal layer of epithelia, probably targeting cells with stemness features, and exploits host replication machinery for viral DNA synthesis. As infected cells differentiate while moving up in the epithelium, viral proteins are synthesized allowing assembly of viral particles and their release with exfoliated epithelial cells. Most HPV infections are cleared within two years; however, in some cases, infection may persist, especially with the so-called high-risk HPV types, which are drivers for malignant transformation. High-risk HPVs, especially HPV16 and HPV18, are the causative agents of virtually all cases of cervical cancer and of a proportion of other ano-genital malignancies and head and neck squamous cell carcinomas.
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3279249
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