Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic multicentric study

Agha, Hm; AbdelMassih, Af; AbdelRahman, My; Milanesi, O; Castaldi, B; Geranio, Giulia; Putti, Mc; Kharabish, A; Esmail, R; El-Kamah, G; Hamdy, M; El-Baz, H; Behairy, N; Hanna, C; El-Tagy, H; Mishriky, Ma; Mamdouh, M; Antonazzo, Livio; Ramadan, T

doi:10.1002/pbc.27272

The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2* with a 100% sensitivity and specificity (cut-off value of 0.34) to discriminate between patients with and without myocardial iron overload.

Titolo:	Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic multicentric study
Autori:	Agha HM AbdelMassih AF AbdelRahman MY MILANESI, ORNELLA CASTALDI, BIAGIO GERANIO, GIULIA Putti MC Kharabish A Esmail R El-Kamah G Hamdy M El-Baz H Behairy N Hanna C El-Tagy H Mishriky MA Mamdouh M ANTONAZZO, LIVIO Ramadan T mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Rivista:	PEDIATRIC BLOOD & CANCER
Abstract:	The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2 with a 100% sensitivity and specificity (cut-off value of 0.34) to discriminate between patients with and without myocardial iron overload.
Handle:	http://hdl.handle.net/11577/3280738
Appare nelle tipologie:	01.01 - Articolo in rivista

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