From fetal life until cardiac surgery, complex congenital heart diseases (CHD) exhibit different hemodynamic and oxygenation patterns that can lead to alteration of the metabolic profile. We used a metabolomic approach to identify urine metabolic markers before cardiac surgery, aiming to define the physiology of patients with complex CHD and to contribute to predict their neurodevelopmental outcome.
Pre-surgery urine metabolomics may predict late neurodevelopmental outcome in children with congenital heart disease
Vedovelli L.;Cogo P.;Cainelli E.;Suppiej A.;Padalino M.;Tassini M.;Simonato M.;Stellin G.;Buonocore G.;
2019
Abstract
From fetal life until cardiac surgery, complex congenital heart diseases (CHD) exhibit different hemodynamic and oxygenation patterns that can lead to alteration of the metabolic profile. We used a metabolomic approach to identify urine metabolic markers before cardiac surgery, aiming to define the physiology of patients with complex CHD and to contribute to predict their neurodevelopmental outcome.
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