The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies.

Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1

Sanchez-Martin C.;Laquatra C.;Cannino G.;Masgras I.;Negro A.;Rasola A.;
2020

Abstract

The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3338537
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