Sinonasal inverted papilloma (IP) is a benign, locally aggressive epithelial neoplasm. In less than 9% of cases it isassociated with malignancies, typically conventional squamous cell carcinomas (SCC), while other histologicalvariants have been less frequently reported. We describe the third case of basaloid squamous cell carcinoma(BSCC) arising in nasal IP.An 81-year-old female patient presented with a pinkish irregular lesion on the nasal septum. Biopsy wasconsistent with IP and carcinomain situ. Two surgical procedures were needed to obtain radical excision.Histology on the surgical specimen revealed BSCC. Seven months after surgery, there was no evidence of diseaserecurrence.Although IP is more frequently associated with conventional SCC, other malignancies should be considered.The histological differential diagnosis should be supported by immunohistochemistry. The generally-re-commended treatment for sinonasal BSCC is complete surgical resection, although this may be a problem inmultifocal distributions, as in the present case

A rare case of nasal Schneiderian (inverted) papilloma associated with basaloid squamous cell carcinoma.

Parrino D;Carraro V;Alessandrini L;Marioni G.
2020

Abstract

Sinonasal inverted papilloma (IP) is a benign, locally aggressive epithelial neoplasm. In less than 9% of cases it isassociated with malignancies, typically conventional squamous cell carcinomas (SCC), while other histologicalvariants have been less frequently reported. We describe the third case of basaloid squamous cell carcinoma(BSCC) arising in nasal IP.An 81-year-old female patient presented with a pinkish irregular lesion on the nasal septum. Biopsy wasconsistent with IP and carcinomain situ. Two surgical procedures were needed to obtain radical excision.Histology on the surgical specimen revealed BSCC. Seven months after surgery, there was no evidence of diseaserecurrence.Although IP is more frequently associated with conventional SCC, other malignancies should be considered.The histological differential diagnosis should be supported by immunohistochemistry. The generally-re-commended treatment for sinonasal BSCC is complete surgical resection, although this may be a problem inmultifocal distributions, as in the present case
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3339599
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