Distilling the distinct contralateral and ipsilateral attentional responses to lateral stimuli and the bilateral response to midline stimuli for upper and lower visual hemifield locations

A contralateral posterior negativity elicited by lateral oddballs (N2pc) and a bilateral posterior negativity elicited by vertical midline oddballs (bilateral N2) are ERP components reflecting attentional deployment that have been rarely compared. In different tasks, we explored to what extent they reflect similar underlying mechanisms of attention. We used a multiple-frame procedure to present pop-out color oddballs among distractors. A homogeneous condition contained only distractors (0 oddballs) and served as a control condition that was subtracted from oddball-present conditions to isolate attention effects. The number of oddballs and the vertical hemifield containing them (upper vs. lower) were two critical factors. For the lower hemifield, the signal amplitude increased with the number of oddballs, otherwise had similar effects and scalp distributions, suggesting the bilateral N2 acted as a bilateral N2pc and likely reflected similar underlying generators. For the upper hemifield, component amplitude also increased with the number of oddballs, but the scalp distributions were positive and more centered, suggesting inverted generators across the two vertical hemifields. An ipsilateral positivity occurred about 50 ms after a contralateral positivity, similar in magnitude, producing a biphasic contra-minus-ipsi difference wave. Previously reported smaller negative N2pc components for upper hemifield oddballs likely reflected a negative lobe artificially created by the subtraction of a lagged positive ipsilateral response. The results compel us to argue for a systematic separation of data for upper versus lower hemifields in studies of visuo-spatial attention, and the use of an experimental design permitting the separate estimation of contralateral and ipsilateral responses.