Aim:Squamous cell carcinoma antigen immune-complexed with immunoglobulin M (SCCA-IgM) is a useful but not completely satisfactory biomarker of hepatocellular carcinoma (HCC). Considering its gender-specific behavior in preclinical models, we investigated gender-related differences of SCCA-IgM as a prognostic marker in HCC.Patients & methods:Two hundred and eight prospectively recruited patients treated with transarterial chemoembolization in a single tertiary care hospital were retrospectively evaluated. Correlations between SCCA-IgM levels, clinical characteristics and survival were assessed according to gender.Results:When the disease was advanced, SCCA-IgM was higher in males and lower in females. Levels below 130 AU/ml predicted a significantly longer survival in males (p = 0.007) and a shorter survival in females (p = 0.01).Conclusion:In predicting the prognosis of HCC patients, the interpretation of SCCA-IgM should consider gender as a relevant variable.

SCCA-IgM in hepatocellular carcinoma patients treated with transarterial chemoembolization: gender-related differences

Pelizzaro, Filippo;Soldà, Federica;Cardin, Romilda;Imondi, Angela;Sartori, Anna;Penzo, Barbara;Sammarco, Ambra;Vitale, Alessandro;Cillo, Umberto;Farinati, Fabio
2020

Abstract

Aim:Squamous cell carcinoma antigen immune-complexed with immunoglobulin M (SCCA-IgM) is a useful but not completely satisfactory biomarker of hepatocellular carcinoma (HCC). Considering its gender-specific behavior in preclinical models, we investigated gender-related differences of SCCA-IgM as a prognostic marker in HCC.Patients & methods:Two hundred and eight prospectively recruited patients treated with transarterial chemoembolization in a single tertiary care hospital were retrospectively evaluated. Correlations between SCCA-IgM levels, clinical characteristics and survival were assessed according to gender.Results:When the disease was advanced, SCCA-IgM was higher in males and lower in females. Levels below 130 AU/ml predicted a significantly longer survival in males (p = 0.007) and a shorter survival in females (p = 0.01).Conclusion:In predicting the prognosis of HCC patients, the interpretation of SCCA-IgM should consider gender as a relevant variable.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3350930
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