Animals use relief-based place learning to pinpoint a specific location where noxious stimuli are diminished or abolished. Here we show how the optogenetically-induced activation of bitter-sensing neurons in Drosophila melanogaster elicits pain-like behavioural responses and stimulates the search for a place where this activation is relieved. Under this “virtual” stimulation paradigm it would be feasible to test relief learning several times throughout an animal's lifespan, without the potentially damaging effects which may result from the repeated administration of “real” heat or electrical shock. Furthermore, virtual bitter taste could be used in place of virtual pain stimulation to guide conditioned place preference and study learning processes. We also propose that spatially-specific reduction of locomotor velocity may provide immediate evidence of relief-based place learning and spatial memory.

Searching for relief: Drosophila melanogaster navigation in a virtual bitter maze

Meda N.;Frighetto G.;Megighian A.
;
Zordan M. A.
2020

Abstract

Animals use relief-based place learning to pinpoint a specific location where noxious stimuli are diminished or abolished. Here we show how the optogenetically-induced activation of bitter-sensing neurons in Drosophila melanogaster elicits pain-like behavioural responses and stimulates the search for a place where this activation is relieved. Under this “virtual” stimulation paradigm it would be feasible to test relief learning several times throughout an animal's lifespan, without the potentially damaging effects which may result from the repeated administration of “real” heat or electrical shock. Furthermore, virtual bitter taste could be used in place of virtual pain stimulation to guide conditioned place preference and study learning processes. We also propose that spatially-specific reduction of locomotor velocity may provide immediate evidence of relief-based place learning and spatial memory.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3352178
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact