A set of four organogelators from an a-amino acid derivative to a tetrapeptide, covalently linked to an acetylenic moiety, was studied in terms of polymerization efficiencies to afford peptide polyacetylenes and polydiacetylenes. Peptides were designed to improve the organogelator behavior via formation of intermolecular H-bonding-mediated b-sheet networks as a function of their mainchain length. The polymerization experiments were run under appropriate conditions for the various monomers with the aim at elucidating how the monomer self-assembly process might influence polymer formation. Starting compounds and their corresponding polymers were characterized by a variety of spectroscopic and microscopic techniques.

From self-assembled peptide-ynes to peptide polyacetylenes and polydiacetylenes

Giulia Marafon;Claudio Toniolo;Alessandro Moretto
2018

Abstract

A set of four organogelators from an a-amino acid derivative to a tetrapeptide, covalently linked to an acetylenic moiety, was studied in terms of polymerization efficiencies to afford peptide polyacetylenes and polydiacetylenes. Peptides were designed to improve the organogelator behavior via formation of intermolecular H-bonding-mediated b-sheet networks as a function of their mainchain length. The polymerization experiments were run under appropriate conditions for the various monomers with the aim at elucidating how the monomer self-assembly process might influence polymer formation. Starting compounds and their corresponding polymers were characterized by a variety of spectroscopic and microscopic techniques.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3367794
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