INTRODUCTION: Paediatric patients are particularly prone to cardiopulmonary bypass (CPB)-induced coagulopathy mainly due to haemodilution, consumption of coagulation factors and hypothermia. The aim of the present study was to examine the possible role of platelet count and function as it relates to the bleeding risk after CPB in the paediatric population.MATERIALS AND METHODS: All consecutive patients (age <13 years) scheduled for elective cardiac surgery between January 2019 and November 2019 were retrospectively considered for the study. We gathered demographic characteristics, perioperative laboratory data (mainly platelet count and function), transfusion requirements and blood loss for each patient. Patients with a chest tube output during the first 24 hours after surgery >75th percentile were bleeders (cases). Controls were non-bleeders.RESULTS: A total of 31 patients were enrolled [median age 17 (4-57) months]. A significant postoperative reduction in platelet count (p < 0.001) and function either in ADP-test (p <0.001), TRAP-test (p <0.001) and ASPI-test (p <0.001) was found, with positive correlations between chest tube output within the first 24 hours after surgery and postoperative impairment of platelet count (R = 0.553, p = 0.001), ADP-test (R = 0.543, p = 0.001), TRAP-test (R = 0.627, p <0.001) and ASPI-test (R = 0.436, p = 0.014). Eight children (26%) experienced major postoperative bleeding. Bleeders were significantly younger (p = 0.015) and underwent longer CPB duration (p = 0.015). Despite no significant differences in postoperative platelet count and function between cases and controls, the postoperative reduction (Delta) in platelet count (p = 0.002) and function in ADP-test (p = 0.007), TRAP-test (p = 0.020) and ASPI-test (p = 0.042) was significantly greater in bleeders vs. non-bleeders. A DeltaPLT >262500 x109 /L, a DeltaADP-test >29 U, a DeltaTRAP-test >44 U and a DeltaASPI-test >26 U showed to be predictive of major postoperative bleeding.CONCLUSIONS: Postoperative bleeding in children undergoing cardiac surgery with CPB was linked to younger age, longer CPB duration and significant postoperative reduction in platelet count and function. Larger studies are needed to confirm our results and define strategies to reduce postoperative bleeding in these patients.

Cardiopulmonary bypass-induced coagulopathy in paediatric patients: the Role of Platelets in postoperative bleeding. A preliminary study

Sella, Nicolò;Spiezia, Luca;Menin, Eugenia;Vida, Vladimiro;Simioni, Paolo;
2021

Abstract

INTRODUCTION: Paediatric patients are particularly prone to cardiopulmonary bypass (CPB)-induced coagulopathy mainly due to haemodilution, consumption of coagulation factors and hypothermia. The aim of the present study was to examine the possible role of platelet count and function as it relates to the bleeding risk after CPB in the paediatric population.MATERIALS AND METHODS: All consecutive patients (age <13 years) scheduled for elective cardiac surgery between January 2019 and November 2019 were retrospectively considered for the study. We gathered demographic characteristics, perioperative laboratory data (mainly platelet count and function), transfusion requirements and blood loss for each patient. Patients with a chest tube output during the first 24 hours after surgery >75th percentile were bleeders (cases). Controls were non-bleeders.RESULTS: A total of 31 patients were enrolled [median age 17 (4-57) months]. A significant postoperative reduction in platelet count (p < 0.001) and function either in ADP-test (p <0.001), TRAP-test (p <0.001) and ASPI-test (p <0.001) was found, with positive correlations between chest tube output within the first 24 hours after surgery and postoperative impairment of platelet count (R = 0.553, p = 0.001), ADP-test (R = 0.543, p = 0.001), TRAP-test (R = 0.627, p <0.001) and ASPI-test (R = 0.436, p = 0.014). Eight children (26%) experienced major postoperative bleeding. Bleeders were significantly younger (p = 0.015) and underwent longer CPB duration (p = 0.015). Despite no significant differences in postoperative platelet count and function between cases and controls, the postoperative reduction (Delta) in platelet count (p = 0.002) and function in ADP-test (p = 0.007), TRAP-test (p = 0.020) and ASPI-test (p = 0.042) was significantly greater in bleeders vs. non-bleeders. A DeltaPLT >262500 x109 /L, a DeltaADP-test >29 U, a DeltaTRAP-test >44 U and a DeltaASPI-test >26 U showed to be predictive of major postoperative bleeding.CONCLUSIONS: Postoperative bleeding in children undergoing cardiac surgery with CPB was linked to younger age, longer CPB duration and significant postoperative reduction in platelet count and function. Larger studies are needed to confirm our results and define strategies to reduce postoperative bleeding in these patients.
2021
File in questo prodotto:
File Dimensione Formato  
Di Gregorio Cardiopulmonary bypass induced coagulopathy in pediatric patients Artificial organs 2021.pdf

Open Access dal 02/01/2022

Tipologia: Preprint (submitted version)
Licenza: Accesso libero
Dimensione 944.54 kB
Formato Adobe PDF
944.54 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3378527
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 7
  • OpenAlex ND
social impact