Valutazione dei dati sperimentali per la neurotossicità dello sviluppo dei pesticidi

EVALUATION OF EXPERIMENTAL DATA FOR DEVELOPMENTAL NEUROTOXICITY OF PESTICIDES. Epidemiological studies on neurodevelopmental effects of pesticides are inconclusive. Experimental developmental neurotoxicity studies, sometimes show effects on pups given doses lower than adults; most of the times these effects were transient, aspecific, with scattered biochemical, molecular or neurobehavioural changes, generally associated with high bolus doses. At repeated low doses, effects in pups did not occur at doses lower than in adults.Since the effects of high bolus doses are possible, preventive interventions should aim at reducing these exposures.