The characteristic features of kinin B1 and B2 receptors are analyzed. Emphasis is placed on the pharmacologic profiles of B1 and B2 functional sites by the use of naturally-occurring kinins, some selective agonists, as well as peptide and non-peptide antagonists. Species differences are indicated, particularly between human, rabbit and mouse B1 receptors and also between human, rabbit and guinea pig B2 receptors. Extensive use has been made of the non-peptide B2 receptor antagonist, WIN-64338 (which is active in the guinea pig and inactive in the other species) and FR-173657 which shows high affinity in human, rabbit, mouse, pig and guinea pig B2 receptors.
B1 and B2 kinin receptors in various species
CALO', Girolamo;
1997
Abstract
The characteristic features of kinin B1 and B2 receptors are analyzed. Emphasis is placed on the pharmacologic profiles of B1 and B2 functional sites by the use of naturally-occurring kinins, some selective agonists, as well as peptide and non-peptide antagonists. Species differences are indicated, particularly between human, rabbit and mouse B1 receptors and also between human, rabbit and guinea pig B2 receptors. Extensive use has been made of the non-peptide B2 receptor antagonist, WIN-64338 (which is active in the guinea pig and inactive in the other species) and FR-173657 which shows high affinity in human, rabbit, mouse, pig and guinea pig B2 receptors.Pubblicazioni consigliate
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