Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial

Pearse, Rupert;Ranieri, Marco;Abbott, Tom;Pakats, Mari-Liis;Piervincenzi, Edoardo;Patel, Akshaykumar;Kahan, Brennan;Rhodes, Andrew;Dias, Priyanthi;Hewson, Russell;Jammer, Ib;Chew, Michelle;Aldecoa, Cesar;Rodseth, Reitze;Biccard, Bruce;Stephens, Tim;Payne, Sara;Hepworth, David;Pischke, Soeren;Asvall, Joerund;Hausken, John;Jhanji, Shaman;Rooms, Martin;Flint, Neil;Hales, Dawn;Szakmany, Tamas;Leitch, Andrew;Spadaro, Savino;Chiumello, Davide;Johnston, Paul;Yeung, Joyce;Tellan, Guglielmo;Veenith, Tonny;Macmillan, Josep;Terragni, Pierpaolo;Sander, Caroline;Kasipandian, Vidya;Ahmad, Tahania;Lee, Aaron;Tammaro, Marcello;McAuley, Danny;Skene, Simon;Vohra, Ravinder;Wilson, Matt;Edwards, Mark;Griffiths, Ewen;Pritchard, Naomi;Filippini, Claudia;Aasmundstad, Tor;Aksnes, Einar;Alpers, Lise-Merete;Barratt-Due, Andreas;Dahl, Anita;Feldt, Linda;Figari, Elisa;Flåten, Eva;Granheim, Karen;Hagring, Minna;Haugaa, Håkon;Kjoesen, Gisle;Klaevahaugen, Inge;Lenz, Harald;Myhre, Marianne;Orrem, Hilde;Stitt, Emily;Toennessen, Tor Inge;Al-Kadhimi, Samuel;Anker, Robert;Balint, Mihaela;Barraclough, Lauren;Black, Ethel;Clayton, Matt;Conneely, Leonora;Edwards, Zara;Eeles, Alex;Evans, Matthew;Gerstman, Michelle;Greenshields, Nicole;Harvey, Eleanor;Hegarty, Aoife;Hester, Natalie;Hutchinson, Jenna;Kasivisvanathan, Ramanathan;Lawrence, Helen;Marsh, Veronica;Matthews, Laura;Mazzola, Francesca;McCanny, Jamie;Morrison, Ben;O'Mahony, Michelle;Pang, Ching Ling;Parkinson, David;Pirie, Katrina;Rao Baikady, Ravishankar;Shovel, Louisa;Smith, Lorna;Tatham, Kate;Thomas, Peter;Uren, Sophie;Walker, Susanna;Wills, Alasdair;Andreou, Prematie;Howson, Alex;Kaur, Jasmin;Lewszuk, Adam;Molina, Esther;Ramsamy, Nirmalabaye;Roberts, Emma;Amaral, Vanessa;Begum, Salma;Bekele, Soliana;Cashmore, Richard;Correia, Carmen;Dunkley, Steven;Fernandez, Maria;Fowler, Alexander;Garcia, Amaia;Della Giovampaola, Maria;Greaves, Kathryn;Griffiths, Bethan;Haines, Ryan;Haslop, Richard;Hu, Ying;Hui, Sarah;Januszewska, Marta;Manon, Vasi;Martin, Tim;May, Shaun;Minicozzi, Annamaria;Niebrzegowska, Edyta;Oliveira, Monica;Pates, Katherine;Santos, Filipa;Shahid, Tasnin;Simili, Paolo;Somerville, Alastair;Subhedar, Emily;Uddin, Ruzena;Walker, Sophie;Wan, Yize;Whalley, Jan;Zolfaghari, Parjam;Gunter, Una;Hodkinson, Gemma;Howe, Gwenllian;Baratozzi, Valentina;Casotto, Giulia;Darai, Giulia;Ferrari, Erica;Mistraletti, Giovanni;Palmaverdi, Valentina;Furlani, Stefano;Priani, Paolo;Ragazzi, Riccardo;Salmaso, Marco;Verri, Marco;Volta, Carlo;Nutt, Chris;McKay, Emma;O'Neill, Orla;Patel, Jaimin;Atterbury, Katie;Ballinger, Sarah;Carling, Natalie;Ellis, Kaytie;Gresty, Jo;Melody, Teresa;Monk, Jade;Norman, Chloe;Reeves, Eleanor;Sampson, Julia;Sutton, Peter;Thomas, Marie;Bamford, Amy;Bergin, Colin;Carrera, Ronald;Cooper, Lauren;Despy, Liesl;Ellis, Karen;Fellows, Emma;Goundry, Stephanie;Harkett, Samantha;Ip, Peter;Mason, Tracy;McGhee, Christopher;McLaughlin, Aisling;Neal, Aoife;Pope, Martin;Porter, Stephanie;Smith, Hazel;Snelson, Catherine;Spruce, Elaine;Vigo, Ylenia;Whitehouse, Arlo;Whitehouse, Tony;Donatiello, Maria;Gazzanelli, Sergio;Mezzapesa, Mario;Savino, Martina;Settesoldi, Giacomo;Kunst, Gudrun;Birch, Sian;Greig, Louise;Noble, Harriet;Pappa, Evita;Penhaligon, Bethany;Cossu, Andrea;Floris, Leda;Piredda, Davide;Racca, Alberto;Brattstrom, Olof;Heggelund, Bente;Flodberg, Magnus;Månsson, Sandra;Ahmed, Mamoona;Allen, Jonathan;Bell, Paula;Genetu, Roman;Glennon, Julia;Hanley, Janice;Jenner, Katy;Jogi, Summayyah;Mahjoob, Parisa;McGovern, Clare;Murphy, Anthony;Nazari, Roonak;Routledge, Jacki;Uttamlal, Trishna;Ward, Sinead;Iotti, Giorgio;Picchioni, Raffaella;Poma, Silvia;Navalesi, Paolo;Bruni, Andrea;De Leonardis, Brunella;Garofalo, Eugenio;Patel, Panna;McArthur, Carol;Burns, Karen;Peters, Steven;Foti, Giuseppe;Calcinati, Serena;Grassi, Alice;Villa, Silvia;Berridge, John;Kanakaraj, Muthuraj;Cahill, Hazel;Forshaw, Greg;Gibson, Andy;Grainger, Lia;Howard, Kate;James, Katherine;Murphy, Zoe;Sweeting, Helen;Tait, Rebecca;Wilcock, Danielle;Yates, David;Cope, Sean;Allan, Ashley;Betts, Rebecca;Cornell, Sarah;Sheriff, Julie;Woods, Lindsey;Grasselli, Giacomo;Brioni, Matteo;Castagna, Luigi;von Rahden, Richard;Farina, Zane;Green, Samantha;Gumede, Simphiwe;Rajah, Chantal;Ramkillawan, Arisha;Moug, Susan;Alcorn, David;Dalton, Carol;Dickinson, Natalie;Edwards, Jennifer;Henderson, Steven;McIlveen, Erin;Ramsaran, Richard;Bell, Joanne;Fleming, Lorna;Monks, Kathleen;Parker, Jane;Stamper, Sean;Stokes-Denson, Jo;Elías, Elisa;Guerra, Yessica;Rico-Feijoo, Jesus;Kidel, Carlos;Filipe, Helder;Asis, Gretchelle;Gleeson, Yvonne;Harvey, Alice;Jackson, Christine;McNeil, Margaret;Mingo, Sara;Pakou, Glykeria;Pinto, Manuel;Wright, Stephen;Babio-Galan, Maite;Buckley, David;Calder, Verity;Chishti, Ahmad;Cosgrove, Joseph;Cullen, Katherine;Dunn, Leigh;Faulds, Matthew;Fortune, Jonathan;Gardner, Matthew;Harrison, Abigail;Hays, Carole;Jones, Gerry;Macfie, Caroline;Mccullagh, Iain;Nesbitt, Ian;O'Neil, Suzanne;Phoenix, Catherine;Rangaswamy, Girish;Samson, Craig;Scott, Carmen;Shrestha, Tara;Singh, Rita;Soulsby, Graham;Walton, Jon;Zwiggelaar, Kimberley;Lynch, Ceri;Clarke, Heidi;Deacon, Bethan;Ivatt, Helen;Jones, Leanne;Latif, Ahmed;Oram, Shaun;Perman, Chris;Roche, Lisa;Duys, Rowan;Flint, Margot;Bhagwan, Kamal;Coetzee, Ettienne;Joubert, Ivan;Montoya-Pelaez, Felipe;Navsaria, Pradeep;Picken, Guy;Porrill, Owen;Strathie, Grant;Zungu, Thembinkosi;Aluri, Sireesha;Chau, Simon;Cooper, Deborah;Cunningham, Mishell;Daniels, Allison;Hope, Susan;Nicholson, Alice;Walker, Laura;Giarratano, Antonino;Accurso, Giuseppe;Raineri, Santi;Tricoli, Giuseppe;Innes, Richard;Doble, Patricia;Hutter, Joanne;Pawley, Corinne;Tait, Moira;Hamilton, Mark;Andrade, Edward;Barnes, Veronica;Dalton, Claire;Delgado, Carlos;Farnell-Ward, Sarah;Farrah, Helen;Gray, Geraldine;Hegarty, Aoife;Howlett, Luisa;Joseph, Gipsy;Krupa, Monika;Leaver, Susannah;Macedo, Joao;Maher, Karen;Mellinghoff, Johannes;Oguntimehin, Rachel;Pereira, Joel;Robinson, Frances;Ryan, Christine;Shah, Nirav;Shirley, Paula;Torborg, Alexandra;Biyase, Thuli;Drummond, Leanne;Kusel, Belinda;Mbuyisa, Mbalenhle;Solala, Sivuyisiwe;Taylor, Jenna;Ezihe-Ejiofor, Adanma;Aduse-Poku, Maame;Colville, Gary;Davies, Louise;Kang, Soo;Phillips, Alex;Kirk-Bayley, Justin;Kelliher, Leigh;Carvelli, Paula;Daysal, Gokce;Dickinson, Matthew;Doyle, Nancileigh;Hughes, Christina;Montague, Laura;Potter, Elizabeth;Salberg, Armorel;Sibug, Sheena;Sivarajan, Sinduja;Thomson, Milo;Wakeford, Nichola;Rocco, Monica;Alampi, Daniela;Conway, Daniel;Clark, Richard;Maria, Jashmin;Pomeroy, Fiona;Quraishi, Tanviha;Williams, Abigail;Chukkambotla, Srikanth;Aherne, Caroline;Harrison-Briggs, Donna;Fitchett, Jill;Duberley, Stephen;Zanoni, Andrea;Cardinale, Daniela;Righi, Claudia;Blunt, Mark;Fuller, Tracy;Hodgson, Ruth;Rosbergen, Melissa;Brennan, Andrew;Akeroyd, Louise;Boardman, Victoria;Bull, Christopher;Carrick, Mike;Chadderton, Ian;Cooper, Sarah;Goellner, Sarah;Graham, Laura;Ilyas, Carl;King, James;Laklouk, Muhammad;Lawton, Tom;Macrow, Christopher;Munro, Michael;Neep, Adam;Northey, Martin;Peacock, Victoria;Pye, Kate;Radley, Lydia;Sira, James;Smithson, Beth;Syddall, Stuart;Tooth, David;White, Thomas;Hoel, Sindre;Aakre, Elin;Bakke, Monica;Hoivik, Tone;Makowski, Arystarch;Alcock, Harry;Cardoso, Sean;Coetzee, Samantha;Everett, Mary;Ibrahim, Mohamed;Kouridaki, Christina;Ogbeide, Vongayi;Bertellini, Elisabetta;Bertolotti, Valentina;Buono, Antonio;Fanigliulo, Maria;Kumar, Ram;Richards, Nicole;Allana, Alisha;Bacciarelli, Samantha;Barker, Helen;De Bois, Jessica;Bradley, Isabel;Crooks, Jennifer;Daum, Peter;Feben, Alex;Gannon, Lizzie;Kipling, Sarah;Peetamsingh, Andrew;Quamina, Charlotte;Sethi, Sahiba;Sivadhas, Harry;Sollesta, Kathryn;Swain, Andrew;Tan, Evalyn;Willis, Joan;Zou, Maggie;Cranshaw, Julius;Barratt, Nina;Bowman, Katie;Branney, Debbie;Letts, Maria;Pitts, Sally;Day, Christopher;Benyon, Sarah;Eddy, Sara;Green, Adam;Grice, Anna;Kelly, Sinéad;Mackle, Daisy;Mariano, Victor;Park, Linda;Sibley, Pauline;Spencer, William;Bignami, Elena;Bellini, Valentina;Forfori, Francesco;Curci, Maria;Leo, Alessandra;Jackson, Matthew;Awolesi, Jennifer;Hodgkinson, Sheila;Kent, Alissa;Leonard, Dee;Stapleton, Claire;Tibke, Clare;Alexander-Sefre, Farhad;Campey, Lorraine;Hall, Kathryn;Spimpolo, Jennifer;Nilsson, Malin;Didriksson, Helen;Hamilton, Emma;Carnahan, Mandy;Mowatt, Chris;Stickley, Jo;Corcione, Antonio;Rossi, Giuseppe;Fladby, Hege;Andersen, Nina;Bjoernå, Gunhild;Reite, Mads;Roertveit, Linda;Seidel, Philipp;Arnold, Glenn;Benavente, Melissa;Chattersingh, Anjalee;Chironga, Nyasha;Hornzee, Gillian;Kibaru, Joyce;Malik, Ihtisham;McLeavy, Laura;Pathmanathan, Byiravey;Prior, Florence;Strudwick, Rhea;Vezyrgiannis, Marios;Sinha, Aneeta;Babu, Sheeba;Batuwitage, Bisanth;Daly, Zoe;Ellinor, Katharine;Hawes, Elizabeth;Holmes, Ann;Hudson, Karen;Nightingale, Jeremy;Le Poidevin, Alison;Roberts, Lindsey;Kubisz-Pudelko, Agnieszka;Allison, Joanna;Pippard, Lucy;Hamlyn, Vincent;Organ, Angie;Ezihe-Ejiofor, Adanma;Prabhahar, Thaventhran;Bridger, Hayley;Dvorkin, Lee;Manhas, Vitul;Vincent, Rachel;Laha, Shondipon;Cromie, Terri-Louise;Doyle, Donna;Howarth, Rachel;Verlander, Mark;Watt, Ailsa;Williams, Alexandra;Antonelli, Massimo;Cutuli, Salvatore;Montini, Luca;Graterol, Juan;Adams, Benita;Bean, Sarah;Burt, Karen;Hammonds, Fiona;Jigajinni, Suyogi;Fulton, Laura;Kinghorn, Stephen;Mullenheim, Jost;Baillie, Kirsty;Cain, Martyn;Colling, Kerry;Hannaway, Carol;Corso, Ruggero;Calli, Morena;Ferrando, Carlos;Romero, Esther;Jorge-Monjas, Pablo;Soria-García, María;Gómez-Herreras, José;Rodríguez-Jiménez, Rita;De Prada-Martín, Blanca

2021