Rethinking biomedicine in the age of translational research: Organisational, professional, and epistemic encounters

In the most recent decade, translational research (TR) has played a pivotal role in the production and circulation of medical knowledge and technologies, thus redefining biomedicine's moral force, its cultural authority, and its status in society. As a major component of contemporary life sciences, TR—or more commonly, translational biomedicine—aims to transfer more quickly and effectively the findings of basic science into therapeutic interventions for patients by means of innovative organisational arrangements, research methodologies, protocols, and professional roles. This article brings together sociological research examining translational biomedicine from different perspectives to accomplish two goals. First, it offers a comprehensive introduction to the social science debate concerning the growing adoption of a TR framework in biomedicine, with a special focus on the organisational, professional, and epistemological issues. Second, the article has an operational purpose to raise questions about the main methodological repercussions for social scientists facing the investigation of TR as a complex and multi-sited phenomenon that challenges traditional qualitative/quantitative research approaches.