Ebselen was originally developed as a glutathione peroxidase mimic in the treatment of stroke (Parnham & Sies, 2013), and recently explored as a safer alternative to lithium in the treatment of bipolar disorder (Singh et al., 2013). Coincidentally, using magnetic resonance spectroscopy (MRS) we discovered that ebselen reduces glutamate and Glx (glutamate+glutamine) in the anterior cingulate cortex of healthy volunteers (Masaki et al., 2016), consistent with it being an inhibitor of glutaminase enzyme (Thomas et al., 2013).
Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission
Veronese M.;
2020
Abstract
Ebselen was originally developed as a glutathione peroxidase mimic in the treatment of stroke (Parnham & Sies, 2013), and recently explored as a safer alternative to lithium in the treatment of bipolar disorder (Singh et al., 2013). Coincidentally, using magnetic resonance spectroscopy (MRS) we discovered that ebselen reduces glutamate and Glx (glutamate+glutamine) in the anterior cingulate cortex of healthy volunteers (Masaki et al., 2016), consistent with it being an inhibitor of glutaminase enzyme (Thomas et al., 2013).File in questo prodotto:
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