MDSCs and T cells in solid tumors and non-Hodgkin lymphomas: an immunosuppressive speech

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of cells expanded during multiple pathological settings, including cancers. In tumors, MDSCs are dominant drivers of T-cell immunosuppression. To accomplish their job, they exploit multiple mechanisms ultimately leading to the paralysis of anti-tumor immunity. Among the variety of MDSC-ways of working within the tumor microenvironment, the generation of reactive species and the metabolic reprogramming have emerged as pivotal determinants of their immunosuppressive power. In this review we will overview integral mechanisms of MDSC-mediated immunosuppression in solid tumors, with a particular focus on Non-Hodgkin lymphoma.Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of cells orchestrating T cell immunosuppression in tumors. To accomplish their job, MDSCs exploit multiple mechanisms of action, including the metabolic reprogramming of T cells and the generation of reactive species. This review focuses on key mechanisms of MDSC-mediated immunosuppression in solid tumors, in particular in Non-Hodgkin lymphoma.