Objective: To identify the potential prognostic value of lymphocyte subsets in COVID-19 patients, where lymphopenia is a common finding. Methods: In 353 COVID-19 inpatients and 40 controls T cell subsets with markers of senescence and exhaustion were studied by flow cytometry. Results: In severe illness, total lymphocytes B, NK, and all T subsets were dampened. Senescent CD4+, but mainly CD8+ T cells, increased in patients with respect to controls. The most significant index predicting fatal outcome was neutrophils/CD3+ T ratio. Conclusion: In conclusion, an altered T cell pattern underlies COVID-19 severity and is involved in predicting the outcome.

T Cell Senescence by Extensive Phenotyping: An Emerging Feature of COVID-19 Severity

Zuin, Jenny;Fogar, Paola;Musso, Giulia
;
Padoan, Andrea;Pelloso, Michela;Tosato, Francesca;Cattelan, Annamaria;Basso, Daniela;Plebani, Mario
2022

Abstract

Objective: To identify the potential prognostic value of lymphocyte subsets in COVID-19 patients, where lymphopenia is a common finding. Methods: In 353 COVID-19 inpatients and 40 controls T cell subsets with markers of senescence and exhaustion were studied by flow cytometry. Results: In severe illness, total lymphocytes B, NK, and all T subsets were dampened. Senescent CD4+, but mainly CD8+ T cells, increased in patients with respect to controls. The most significant index predicting fatal outcome was neutrophils/CD3+ T ratio. Conclusion: In conclusion, an altered T cell pattern underlies COVID-19 severity and is involved in predicting the outcome.
2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3451300
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