Phase Angle as a Marker of Muscular Strength in Breast Cancer Survivors

Background: accurate prognostic tools are relevant for decision-making in cancer care. Objective measures, such as bioelectrical impedance (BI), have the potential to improve prognostic accuracy for these patients. This cross-sectional study aimed to investigate whether phase angle (PhA) derived from the electrical properties of the body tissues is a predictor of muscular strength in breast cancer survivors (BCS). Methods: a total of 41 BCS (age 54.6 +/- 9.2 years) were evaluated. PhA, obtained at frequency 50 kHz, was assessed with BI spectroscopy, and muscular strength with a handgrip dynamometer. Moderate-to-vigorous physical activity (MVPA) was assessed using the International Physical Activity Questionnaire (IPAQ). Measurements were performed in the morning after an overnight fast. Results: linear regression analysis showed that PhA accounted for 22% (r(2)= 0.22) of muscular strength variance. PhA remained a borderline predictor of muscular strength variance independently of age and MVPA. Conclusions: the findings of this study suggest that PhA is a significant predictor of maximal forearm isometric strength and a potential indicator of disease-related functionality in BCS.