Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

Bellan, M.; Azzolina, D.; Hayden, E.; Gaidano, G.; Pirisi, M.; Acquaviva, A.; Aimaretti, G.; Aluffi Valletti, P.; Angilletta, R.; Arioli, R.; Avanzi, G. C.; Avino, G.; Balbo, P. E.; Baldon, G.; Baorda, F.; Barbero, E.; Baricich, A.; Barini, M.; Barone-Adesi, F.; Battistini, S.; Beltrame, M.; Bertoli, M.; Bertolin, S.; Bertolotti, M.; Betti, M.; Bobbio, F.; Boffano, P.; Boglione, L.; Borre, S.; Brucoli, M.; Calzaducca, E.; Cammarata, E.; Cantaluppi, V.; Cantello, R.; Capponi, A.; Carriero, A.; Casciaro, G. F.; Castello, L. M.; Ceruti, F.; Chichino, G.; Chirico, E.; Cisari, C.; Cittone, M. G.; Colombo, C.; Comi, C.; Croce, E.; Daffara, T.; Danna, P.; Della Corte, F.; De Vecchi, S.; Dianzani, U.; Di Benedetto, D.; Esposto, E.; Faggiano, F.; Falaschi, Z.; Ferrante, D.; Ferrero, A.; Gagliardi, I.; Galbiati, A.; Gallo, S.; Garavelli, P. L.; Gardino, C. A.; Garzaro, M.; Gastaldello, M. L.; Gavelli, F.; Gennari, A.; Giacomini, G. M.; Giacone, I.; Giai Via, V.; Giolitti, F.; Gironi, L. C.; Gramaglia, C.; Grisafi, L.; Inserra, I.; Invernizzi, M.; Krengli, M.; Labella, E.; Landi, I. C.; Landi, R.; Leone, I.; Lio, V.; Lorenzini, L.; Maconi, A.; Malerba, M.; Manfredi, G. F.; Martelli, M.; Marzari, L.; Marzullo, P.; Mennuni, M.; Montabone, C.; Morosini, U.; Mussa, M.; Nerici, I.; Nuzzo, A.; Olivieri, C.; Padelli, S. A.; Panella, M.; Parisini, A.; Pasche, A.; Patrucco, F.; Patti, G.; Pau, A.; Pedrinelli, A. R.; Percivale, I.; Ragazzoni, L.; Re, R.; Rigamonti, C.; Rizzi, E.; Rognoni, A.; Roveta, A.; Salamina, L.; Santagostino, M.; Saraceno, M.; Savoia, P.; Sciarra, M.; Schimmenti, A.; Scotti, L.; Spinoni, E.; Smirne, C.; Tarantino, V.; Tillio, P. A.; Tonello, S.; Vaschetto, R.; Vassia, V.; Zagaria, D.; Zavattaro, E.; Zeppegno, P.; Zottarelli, F.; Sainaghi, P. P.

doi:10.1155/2021/8863053

Introduction. The clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions. Materials and Methods. In this study, we retrospectively assessed the prognostic value of a simple tool, the complete blood count, on a cohort of 664 patients (F 260; 39%, median age 70 (56-81) years) hospitalized for COVID-19 in Northern Italy. We collected demographic data along with complete blood cell count; moreover, the outcome of the hospital in-stay was recorded. Results. At data cut-off, 221/664 patients (33.3%) had died and 453/664 (66.7%) had been discharged. Red cell distribution width (RDW) (χ2 10.4; p < 0:001), neutrophil-to-lymphocyte (NL) ratio (χ2 7.6; p = 0:006), and platelet count (χ2 5.39; p = 0:02), along with age (χ2 87.6; p < 0:001) and gender (χ2 17.3; p < 0:001), accurately pred...