The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (Delta Psi m) were assessed. SBP was 124 +/- 1 (WKY) and 235 +/- 6 mm Hg (SHR). CRC, Ca2+ response and Delta Psi m were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WRY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: correlation with systolic blood pressure levels

Pardo, Alejandro Ciocci;
2015

Abstract

The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (Delta Psi m) were assessed. SBP was 124 +/- 1 (WKY) and 235 +/- 6 mm Hg (SHR). CRC, Ca2+ response and Delta Psi m were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WRY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
2015
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3474153
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