Background: How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (tau), and expression level, connected?Methods: In order to investigate these relationships, we combined different metrics linked to genetic constraints and analyzed their distribution concerning PPIs, tau and expression levels.Results: We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. On the other hand, we obtained a negative correlation between genetic constraints and tau. Furthermore, the fraction of variance in PPI and tau explained by the constraints metrics is around 6% and 10%, respectively.Conclusions: We observed that the variance of expression of tissue-specific genes seems not related to their level of selection constraints, which is the opposite of what is found on non-tissue-specific genes. Overall these observations would help to elucidate the relationship between natural selection and gene features.
Insights into gene tissue specificity and protein-protein interactions in the context of purifying selection in humans
Mezzavilla, M
Conceptualization
;
2023
Abstract
Background: How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (tau), and expression level, connected?Methods: In order to investigate these relationships, we combined different metrics linked to genetic constraints and analyzed their distribution concerning PPIs, tau and expression levels.Results: We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. On the other hand, we obtained a negative correlation between genetic constraints and tau. Furthermore, the fraction of variance in PPI and tau explained by the constraints metrics is around 6% and 10%, respectively.Conclusions: We observed that the variance of expression of tissue-specific genes seems not related to their level of selection constraints, which is the opposite of what is found on non-tissue-specific genes. Overall these observations would help to elucidate the relationship between natural selection and gene features.Pubblicazioni consigliate
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